Cartilaginous fishes offer unique insights into the evolution of the nuclear receptor gene repertoire in gnathostomes.
Sign Up to like & getrecommendations! Published in 2020 at "General and comparative endocrinology"
DOI: 10.1016/j.ygcen.2020.113527
Abstract: Nuclear receptors (NRs) are key transcription factors that originated in the common ancestor of metazoans. The vast majority of NRs are triggered by binding to either endogenous (e.g. retinoic acid) or exogenous (e.g. xenobiotics) ligands,… read more here.
Keywords: gene repertoire; fishes offer; cartilaginous fishes; offer unique ... See more keywords
The invasive Neisseria meningitidis MenC CC103 from Brazil is characterized by an accessory gene repertoire
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-01671-x
Abstract: Neisseria meningitidis infections are a major issue for global health. The invasive MenC ST-103 clonal complex (CC103) has been the most prevalent in meningococcal outbreaks in Brazil, occurring also in several countries worldwide. Here we… read more here.
Keywords: gene repertoire; cc103; lineage; accessory gene ... See more keywords
Landscape of immunoglobulin heavy chain gene repertoire and its clinical relevance to LPL/WM
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DOI: 10.1182/bloodadvances.2022007279
Abstract: Key Points We unveil the distinct patterns of IGHV repertoire and discuss the correlation between IGHV and other genetic abnormalities in LPL/WM. IGHV4 usage was a predictive marker of shorter progression-free survival in patients with… read more here.
Keywords: heavy chain; chain gene; gene repertoire; immunoglobulin heavy ... See more keywords
T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1097942
Abstract: Background Microenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL patients,… read more here.
Keywords: cell receptor; gene repertoire; gene; genomic aberrations ... See more keywords