One-two punch mechanism of gene repression: a fresh perspective on gene regulation
Sign Up to like & getrecommendations! Published in 2017 at "Current Genetics"
DOI: 10.1007/s00294-017-0793-5
Abstract: Cellular differentiation depends on temporally controlled waves of gene activation and inactivation that ultimately transform one cell type into another. It is well established that transcription factor cascades coordinate the timely activation of gene expression… read more here.
Keywords: gene repression; mechanism; repression; gene ... See more keywords
Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cell"
DOI: 10.1016/j.molcel.2019.03.024
Abstract: Summary The Polycomb system modifies chromatin and plays an essential role in repressing gene expression to control normal mammalian development. However, the components and mechanisms that define how Polycomb protein complexes achieve this remain enigmatic.… read more here.
Keywords: gene repression; variant prc1; polycomb; repression ... See more keywords
Dissecting Gene Repression: Not Just Location, Location, Location.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.06.001
Abstract: Large heterochromatic domains are found tethered to the lamina. But, is this nuclear environment repressive per se, or just the 'ground state' of inactive chromatin? Elegant studies from the van Steensel group (Leemans et al.,… read more here.
Keywords: dissecting gene; location; gene repression; repression location ... See more keywords
Gene repression using synthetic small regulatory RNA in Methylorubrum extorquens.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of applied microbiology"
DOI: 10.1111/jam.15159
Abstract: AIM Genetic tools are a prerequisite for engineering cell factories for synthetic biology and biotechnology. Methylorubrum extorquens is an important platform for a future one-carbon (C1) bioeconomy, but its application is currently limited by the availability… read more here.
Keywords: gene repression; srna; methylorubrum extorquens; rna ... See more keywords
Abstract A056: AR/FOXA1-mediated active gene repression as a mechanism of prostate carcinogenesis
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a056
Abstract: The identity of the prostate gland is defined by transcription factors (TF) like the androgen receptor (AR), FOXA1, and NKX3.1 that bind regulatory elements early in development to activate the lineage gene program. For instance,… read more here.
Keywords: foxa1; gene repression; prostate carcinogenesis; deptor ... See more keywords
Removal of H2Aub1 by ubiquitin-specific proteases 12 and 13 is required for stable Polycomb-mediated gene repression in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Genome Biology"
DOI: 10.1186/s13059-020-02062-8
Abstract: Stable gene repression is essential for normal growth and development. Polycomb repressive complexes 1 and 2 (PRC1&2) are involved in this process by establishing monoubiquitination of histone 2A (H2Aub1) and subsequent trimethylation of lysine 27… read more here.
Keywords: h2aub1; repression; removal h2aub1; gene repression ... See more keywords
Altered expression response upon repeated gene repression in single yeast cells
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1010640
Abstract: Cells must continuously adjust to changing environments and, thus, have evolved mechanisms allowing them to respond to repeated stimuli. While faster gene induction upon a repeated stimulus is known as reinduction memory, responses to repeated… read more here.
Keywords: gene repression; response upon; repression; upon repeated ... See more keywords