A network-based systems biology approach for identification of shared Gene signatures between male and female in COVID-19 datasets
Sign Up to like & getrecommendations! Published in 2021 at "Informatics in Medicine Unlocked"
DOI: 10.1016/j.imu.2021.100702
Abstract: The novel coronavirus (SARS-CoV-2) has expanded rapidly worldwide. Now it has covered more than 150 countries worldwide. It is referred to as COVID-19. SARS-CoV-2 mainly affects the respiratory systems of humans that can lead up… read more here.
Keywords: shared gene; male female; covid; biology ... See more keywords
Artificial intelligence predicts immune and inflammatory gene signatures directly from hepatocellular carcinoma histology.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2022.01.018
Abstract: BACKGROUND AND AIMS Patients with hepatocellular carcinoma (HCC) displaying overexpression of immune gene signatures are likely to be more sensitive to immunotherapy, however the use of such signatures in clinical settings remains challenging. We thus… read more here.
Keywords: hepatocellular carcinoma; histology; gene; artificial intelligence ... See more keywords
A co-expressed gene status of adenylate kinase 1/4 reveals prognostic gene signature associated with prognosis and sensitivity to EGFR targeted therapy in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-48243-9
Abstract: Cancer cells utilize altered bioenergetics to fuel uncontrolled proliferation and progression. At the core of bioenergetics, adenine nucleotides are the building blocks for nucleotide synthesis, energy transfer and diverse metabolic processes. Adenylate kinases (AK) are… read more here.
Keywords: lung adenocarcinoma; gene signature; gene; gene signatures ... See more keywords
AAFL: automatic association feature learning for gene signature identification of cancer subtypes in single-cell RNA-seq data.
Sign Up to like & getrecommendations! Published in 2023 at "Briefings in functional genomics"
DOI: 10.1093/bfgp/elac047
Abstract: Single-cell RNA-sequencing (scRNA-seq) technologies have enabled the study of human cancers in individual cells, which explores the cellular heterogeneity and the genotypic status of tumors. Gene signature identification plays an important role in the precise… read more here.
Keywords: cell; cancer subtypes; gene signatures; feature learning ... See more keywords
FIT, a regulatory hub for iron deficiency and stress signaling in roots, and FIT-dependent and -independent gene signatures
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Experimental Botany"
DOI: 10.1093/jxb/eraa012
Abstract: Abstract Iron (Fe) is vital for plant growth. Plants balance the beneficial and toxic effects of this micronutrient, and tightly control Fe uptake and allocation. Here, we review the role of the basic helix–loop–helix (bHLH)… read more here.
Keywords: independent gene; regulatory hub; fit dependent; gene signatures ... See more keywords
PAGER-CoV: a comprehensive collection of pathways, annotated gene-lists and gene signatures for coronavirus disease studies
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkaa1094
Abstract: Abstract PAGER-CoV (http://discovery.informatics.uab.edu/PAGER-CoV/) is a new web-based database that can help biomedical researchers interpret coronavirus-related functional genomic study results in the context of curated knowledge of host viral infection, inflammatory response, organ damage, and tissue… read more here.
Keywords: pathways annotated; pager cov; annotated gene; gene signatures ... See more keywords
TIRSF: a web server for screening gene signatures to predict Tumor immunotherapy response
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac374
Abstract: Abstract Immune checkpoint blockade (ICB) therapy has been successfully applied to clinically therapeutics in multiple cancers, but its efficacy varies greatly among different patients and cancer types. Therefore, the construction of gene signatures to identify… read more here.
Keywords: tirsf; icb therapy; immunotherapy; gene signatures ... See more keywords
Network exploration of gene signatures underlying low birth weight induced metabolic alterations
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000031489
Abstract: Background: This study explored underlying gene signatures of low birth weight (LBW) by analyzing differentially expressed genes (DEGs) between LBW and normal birth weight (NBW) subjects. Methods: Subjects with different birth weight was collected from… read more here.
Keywords: network; gene signatures; low birth; birth weight ... See more keywords
Identification and Validation of Inflammatory Response-Related Gene Signatures to Predict the Prognosis of Neuroblastoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Genomics"
DOI: 10.1155/2022/2417351
Abstract: Background Neuroblastoma (NB) is the third most common malignant tumor in children. The inflammation is believed to be closely related to NB patients' prognosis. However, there is no comprehensive research to study the role of… read more here.
Keywords: inflammatory response; gene signatures; irrg signatures; response related ... See more keywords
Latent-space embedding of expression data identifies gene signatures from sputum samples of asthmatic patients
Sign Up to like & getrecommendations! Published in 2020 at "BMC Bioinformatics"
DOI: 10.1186/s12859-020-03785-y
Abstract: Background The pathogenesis of asthma is a complex process involving multiple genes and pathways. Identifying biomarkers from asthma datasets, especially those that include heterogeneous subpopulations, is challenging. Potentially, autoencoders provide ideal frameworks for such tasks… read more here.
Keywords: expression data; expression; gene signatures; gene ... See more keywords
Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-017-0825-6
Abstract: BackgroundAstrocyte activation is one of the earliest findings in the brain of methamphetamine (Meth) abusers. Our goal in this study was to identify the characteristics of the astrocytic acute response to the drug, which may… read more here.
Keywords: methamphetamine; response; overexpressed gene; exposure ... See more keywords