Ultrathin 2D Copper(I) 1,2,4-Triazolate Coordination Polymer Nanosheets for Efficient and Selective Gene Silencing and Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced materials"
DOI: 10.1002/adma.202100849
Abstract: Gene silencing holds promise for cancer therapeutics because of its potential to inhibit genes involved in tumor development. However, gene silencing is still restricted by its limited efficacy and safety. Nanoscale coordination polymers (CPs) emerge… read more here.
Keywords: selective gene; photodynamic therapy; gene silencing; efficient selective ... See more keywords
Small Molecule‐Templated DNA Hydrogel with Record Stiffness Integrates and Releases DNA Nanostructures and Gene Silencing Nucleic Acids
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205713
Abstract: Deoxyribonucleic acid (DNA) hydrogels are a unique class of programmable, biocompatible materials able to respond to complex stimuli, making them valuable in drug delivery, analyte detection, cell growth, and shape‐memory materials. However, unmodified DNA hydrogels… read more here.
Keywords: small molecule; dna; hydrogel; gene silencing ... See more keywords
Gene silencing in non‐model insects: Overcoming hurdles using symbiotic bacteria for trauma‐free sustainable delivery of RNA interference
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600247
Abstract: Insight into animal biology and development provided by classical genetic analysis of the model organism Drosophila melanogaster was an incentive to develop advanced genetic tools for this insect. But genetic systems for the over one… read more here.
Keywords: insects; delivery; rna interference; model ... See more keywords
Inhibitory role of lentivirus‐mediated aquaporin‐4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27390
Abstract: Traumatic brain injury (TBI), an acute degenerative pathology of the central nervous system, is a leading cause of death and disability. As the glial scar is a mechanical barrier to nerve regeneration, inhibitory molecules in… read more here.
Keywords: scar; traumatic brain; glial scar; gene silencing ... See more keywords
Smad4 gene silencing enhances the chemosensitivity of human lymphoma cells to adriamycin via inhibition of the activation of transforming growth factor β signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28772
Abstract: There are diverse investigations focused on the therapies of lymphoma. Our research was taken to identify the effects of lentiviral‐mediated Smad4 gene silencing on chemosensitivity of human lymphoma cells to adriamycin (ADM) via transforming growth… read more here.
Keywords: chemosensitivity human; signaling pathway; gene silencing; human lymphoma ... See more keywords
siRNA‐mediated NCAM1 gene silencing suppresses oxidative stress in pre‐eclampsia by inhibiting the p38MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28778
Abstract: Pre‐eclampsia (PE), whose pathophysiology and etiology remain undefined, represents a leading consequence of fetal and maternal mortality and morbidity. Oxidative stress (OS) is recognized to involve in this disorder. In this study, we hypothesized that… read more here.
Keywords: signaling pathway; gene silencing; p38mapk signaling; ncam1 gene ... See more keywords
Construction and application of a gene silencing system using a dual promoter silencing vector in Hypsizygus marmoreus
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.201600291
Abstract: As efficient reverse genetic tools are lacking, molecular genetics research has been limited in Hypsizygus marmoreus. In this study, we firstly constructed a gene‐silencing method using a dual promoter vector (DPV) which was driven by… read more here.
Keywords: gene; silencing system; gene silencing; hypsizygus marmoreus ... See more keywords
Virus-Induced Gene Silencing of Cell Wall Genes in Flax (Linum usitatissimum).
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0751-0_6
Abstract: Plants have developed defense mechanisms against viruses by using an RNA silencing-based process, which has many common features with the endogenous RNA silencing pathway used for regulating the level of transcripts derived from developmental genes.… read more here.
Keywords: induced gene; virus induced; gene silencing; gene ... See more keywords
Targeted Gene Silencing in Malignant Hematolymphoid Cells Using GapmeR.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0771-8_15
Abstract: Delivery of conventional antisense oligonucleotides or small interfering RNA (siRNA) molecules into hematolymphoid cells for targeted gene silencing has been proven to be difficult. Here, we describe a simple protocol to knockdown specific gene(s) in… read more here.
Keywords: hematolymphoid cells; cells using; gene silencing; gene ... See more keywords
Isolation and Identification of Gene-Specific MicroRNAs.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7601-0_14
Abstract: Computer programming has identified hundreds of genomic hairpin sequences, many with functions yet to be determined. Because transfection of hairpin-like microRNA precursors (pre-miRNAs) into mammalian cells is not always sufficient to trigger RNA-induced gene silencing… read more here.
Keywords: mirna; gene silencing; gene; isolation identification ... See more keywords
Model Legumes: Functional Genomics Tools in Medicago truncatula.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8633-0_2
Abstract: Many researchers have sought along the last two decades a legume species that could serve as a model system for genetic studies to resolve specific developmental or metabolic processes that cannot be studied in other… read more here.
Keywords: genomics tools; functional genomics; model; medicago truncatula ... See more keywords