Differential global and MTHFR gene specific methylation patterns in preeclampsia and recurrent miscarriages: A case-control study from North India.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.04.036
Abstract: AIM The purpose of the present study is to evaluate and understand the association of global and MTHFR gene specific methylation in preeclampsia and recurrent miscarriages in light of MTHFR C677T polymorphism. METHODS The subjects… read more here.
Keywords: methylation; mthfr gene; specific methylation; gene specific ... See more keywords
DOPlify, Target Sequence Enrichment and Allele Drop-Out – is there a benefit?
Sign Up to like & getrecommendations! Published in 2019 at "Reproductive BioMedicine Online"
DOI: 10.1016/j.rbmo.2019.03.098
Abstract: Introduction The ability to combine whole genome amplification (WGA) with gene-specific primers in a single PCR reaction to allow both aneuploidy detection (PGT-A) and monogenic disease detection (PGT-M) is an advantage of DOPlify® and the… read more here.
Keywords: wga tse; pcr; gene specific; brca1 ... See more keywords
Agriculture R&D Implications of the CJEU's Gene-Specific Mutagenesis Ruling.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2018.09.004
Abstract: On 25 July 2018, the Court of Justice of the European Union (CJEU) ruled that gene-specific mutagenesis must be regulated as genetically modified organism (GMO) technologies. However, the costs to agricultural research and development (R&D)… read more here.
Keywords: gene specific; implications cjeu; agriculture implications; specific mutagenesis ... See more keywords
Creation of gene-specific rice mutants by AvrXa23-based TALENs
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Integrative Agriculture"
DOI: 10.1016/s2095-3119(16)61411-9
Abstract: Abstract Transcription activator-like effector (TALE) nucleases (TALENs) are increasingly used as a powerful tool for genome editing in a variety of organisms. We have previously cloned the TALE-coding gene avrXa23 from Xanthomonas oryzae pv. oryzae… read more here.
Keywords: based talens; rice; gene specific; avrxa23 based ... See more keywords
CardioClassifier: disease- and gene-specific computational decision support for clinical genome interpretation
Sign Up to like & getrecommendations! Published in 2018 at "Genetics in Medicine"
DOI: 10.1038/gim.2017.258
Abstract: PurposeInternationally adopted variant interpretation guidelines from the American College of Medical Genetics and Genomics (ACMG) are generic and require disease-specific refinement. Here we developed CardioClassifier (http://www.cardioclassifier.org), a semiautomated decision-support tool for inherited cardiac conditions (ICCs).MethodsCardioClassifier… read more here.
Keywords: interpretation; disease gene; disease; decision support ... See more keywords
High-fidelity CRISPR/Cas9- based gene-specific hydroxymethylation rescues gene expression and attenuates renal fibrosis
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-05766-5
Abstract: While suppression of specific genes through aberrant promoter methylation contributes to different diseases including organ fibrosis, gene-specific reactivation technology is not yet available for therapy. TET enzymes catalyze hydroxymethylation of methylated DNA, reactivating gene expression.… read more here.
Keywords: fibrosis; gene expression; gene specific; high fidelity ... See more keywords
vaRHC: an R package for semi-automation of variant classification in hereditary cancer genes according to ACMG/AMP and gene-specific ClinGen guidelines
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad128
Abstract: Abstract Motivation Germline variant classification allows accurate genetic diagnosis and risk assessment. However, it is a tedious iterative process integrating information from several sources and types of evidence. It should follow gene-specific (if available) or… read more here.
Keywords: classification; variant classification; varhc package; gene specific ... See more keywords
ONE-seq: epitranscriptome and gene-specific profiling of NAD-capped RNA
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1136
Abstract: Abstract The hub metabolite, nicotinamide adenine dinucleotide (NAD), can be used as an initiating nucleotide in RNA synthesis to result in NAD-capped RNAs (NAD-RNA). Since NAD has been heightened as one of the most essential… read more here.
Keywords: nad capped; nad; epitranscriptome gene; one seq ... See more keywords
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00537
Abstract: Somatic hypermutation (SHM) plays a critical role in the maturation of antibodies, optimizing recognition initiated by recombination of V(D)J genes. Previous studies have shown that the propensity to mutate is modulated by the context of… read more here.
Keywords: substitution profiles; amino acid; gene specific; substitution ... See more keywords
Digital PCR-Based Characterization of a g10evo-epsps Gene-Specific Matrix Reference Material for Its Food and Feed Detection
Sign Up to like & getrecommendations! Published in 2022 at "Foods"
DOI: 10.3390/foods11131888
Abstract: g10evo-epsps is a novel glyphosate herbicide-resistant gene that has been transferred to various crops such as soybean, corn, cotton, and rice. Here, we developed a gene-specific digital Polymerase Chain Reaction (dPCR) detection method for absolute… read more here.
Keywords: gene specific; copy; g10evo epsps; epsps ... See more keywords
Divergent Mutational Landscapes of Consensus and Minority Genotypes of West Nile Virus Demonstrate Host and Gene-Specific Evolutionary Pressures
Sign Up to like & getrecommendations! Published in 2020 at "Genes"
DOI: 10.3390/genes11111299
Abstract: Our current understanding of the natural evolution of RNA viruses comes largely from consensus level genetic analyses which ignore the diverse mutant swarms that comprise within-host viral populations. The breadth and composition of viral mutant… read more here.
Keywords: minority; gene specific; nile virus; host ... See more keywords