In Vitro Evaluation of Candidate Gene Targets for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9220-1_2
Abstract: Discovery and development of gene targets for cancer therapeutics are lengthy and highly costly processes. Identification and evaluation of candidate gene targets are of fundamental importance. RNA interference allows candidate genes to be specifically and… read more here.
Keywords: gene targets; targets cancer; candidate gene; cancer ... See more keywords
Identification of microRNAs and their gene targets in cytoplasmic male sterile and fertile maintainer lines of pigeonpea
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DOI: 10.1007/s00425-021-03568-6
Abstract: Main conclusion Comparative analysis of genome-wide miRNAs and their gene targets between cytoplasmic male sterile (CMS) and fertile lines of pigeonpea suggests a possible role of miRNA-regulated pathways in reproductive development. Abstract Exploitation of hybrid… read more here.
Keywords: gene targets; cytoplasmic male; targets cytoplasmic; fertile ... See more keywords
Exploring the Potential Mechanism of Xiaokui Jiedu Decoction for Ulcerative Colitis Based on Network Pharmacology and Molecular Docking
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DOI: 10.1155/2021/1536337
Abstract: Introduction Network pharmacology is in line with the holistic characteristics of TCM and can be used to elucidate the complex network of interactions between disease-specific genes and compounds in TCM herbal medicines. Here, we investigate… read more here.
Keywords: gene targets; network; mechanism; pharmacology ... See more keywords
Molecular Mechanism of Dayuan Decoction in the Treatment of Fever Based on Network Pharmacology
Sign Up to like & getrecommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2022/7422383
Abstract: Objective To study the molecular targets and mechanisms of Dayuan Decoction in the treatment of fever. Methods The traditional Chinese medicine system pharmacological database and analysis platform (TCMSP) was used to search for the main… read more here.
Keywords: decoction; dayuan decoction; pharmacology; gene targets ... See more keywords
Identification of Key Gene Targets for Periodontitis Treatment by Bioinformatics Analysis
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DOI: 10.1155/2022/7992981
Abstract: Background Periodontitis is considered to be the leading cause of tooth loss in adults, and it interacts with some serious systemic diseases. Periodontal basic therapy is the cornerstone of periodontal disease treatment and long-term maintenance… read more here.
Keywords: key gene; gene targets; analysis; treatment ... See more keywords
Abstract 3756: miR-145 and its gene targets as therapeutic target and prognostic biomarkers for non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3756
Abstract: Introduction: Our previous study found that miR-145 was downregulated in non-small cell lung cancer (NSCLC) tissues and it could inhibit cell proliferation in transfected NSCLC cells. This study aimed to investigate the potential anticancer effect… read more here.
Keywords: cell; gene targets; lung; cancer ... See more keywords
Aberrant expression of microRNAs 16 and 21 and gene targets in women with unexplained recurrent miscarriage: A case-control study
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Reproductive Biomedicine"
DOI: 10.29252/ijrm.16.10.617
Abstract: Received: 17 February 2018 Revised: 12 June 2018 Accepted: 20 June 2018 Abstract Background: Recurrent miscarriage, as the occurrence of two or more of pregnancy loss before the 20 th wk, can occur for multiple… read more here.
Keywords: women unexplained; gene targets; miscarriage; expression micrornas ... See more keywords
Exploring the mechanism of action of Xuanfei Baidu granule (XFBD) in the treatment of COVID-19 based on molecular docking and molecular dynamics
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DOI: 10.3389/fcimb.2022.965273
Abstract: Purpose The Corona Virus Disease 2019 (COVID-19) pandemic has become a challenge of world. The latest research has proved that Xuanfei Baidu granule (XFBD) significantly improved patient’s clinical symptoms, the compound drug improves immunity by… read more here.
Keywords: gene targets; xuanfei baidu; treatment covid; gene ... See more keywords
Mechanisms of Drug Resistance in Ovarian Cancer and Associated Gene Targets
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DOI: 10.3390/cancers14246246
Abstract: Simple Summary When tumors become resistant to chemotherapeutics, alternative treatment strategies must be explored. Gene targeting provides a personalized and molecular approach to tackling chemoresistance in ovarian cancer. However, to advance the current landscape of… read more here.
Keywords: ovarian cancer; gene targets; resistance; drug ... See more keywords
Integrated Bioinformatics Analysis of Shared Genes, miRNA, Biological Pathways and Their Potential Role as Therapeutic Targets in Huntington’s Disease Stages
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054873
Abstract: Huntington’s Disease (HD) is a progressive neurodegenerative disease caused by CAG repeat expansion in the huntingtin gene (HTT). The HTT gene was the first disease-associated gene mapped to a chromosome, but the pathophysiological mechanisms, genes,… read more here.
Keywords: huntington disease; gene targets; analysis; mir ... See more keywords