Enhancer RNAs: a missing regulatory layer in gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Science China Life Sciences"
DOI: 10.1007/s11427-017-9370-9
Abstract: Enhancers and super-enhancers exert indispensable roles in maintaining cell identity through spatiotemporally regulating gene transcription. Meanwhile, active enhancers and super-enhancers also produce transcripts termed enhancer RNAs (eRNAs) from their DNA elements. Although enhancers have been… read more here.
Keywords: transcription; gene transcription; rnas missing; enhancer rnas ... See more keywords
Receptor potential channels TRPC1/TRPC6 regulate lamina cribrosa cell extracellular matrix gene transcription and proliferation.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental eye research"
DOI: 10.1016/j.exer.2020.107980
Abstract: The lamina cribrosa (LC) in glaucoma is with augmented production of extracellular matrix proteins (ECM) and connective tissue fibrosis. Fundamental pathological mechanisms for this fibrosis comprise fibrotic growth factors and oxidative stress. Transient receptor potential… read more here.
Keywords: gene transcription; proliferation; gene; cell ... See more keywords
Involvement of Brd4 in different steps of the papillomavirus life cycle.
Sign Up to like & getrecommendations! Published in 2017 at "Virus research"
DOI: 10.1016/j.virusres.2016.12.006
Abstract: Bromodomain-containing protein 4 (Brd4) is a cellular chromatin-binding factor and transcriptional regulator that recruits sequence-specific transcription factors and chromatin modulators to control target gene transcription. Papillomaviruses (PVs) have evolved to hijack Brd4's activity in order… read more here.
Keywords: life cycle; brd4; gene transcription;
Calcineurin controls gene transcription following stimulation of a Gαq-coupled designer receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.111553
Abstract: Stimulation of the Gαq-coupled receptors triggers the activation of gene transcription via the rise of intracellular Ca2+. To investigate the role of the Ca2+/calmodulin-dependent phosphatase calcineurin in regulating transcription following Gαq-coupled receptor stimulation, we used… read more here.
Keywords: transcription; calcineurin; stimulation; gene transcription ... See more keywords
Exogenous Chemicals Impact Virus Receptor Gene Transcription: Insights from Deep Learning
Sign Up to like & getrecommendations! Published in 2023 at "Environmental Science & Technology"
DOI: 10.1021/acs.est.2c09837
Abstract: Despite the fact that coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been disrupting human life and health worldwide since the outbreak in late 2019, the impact of exogenous… read more here.
Keywords: exogenous chemicals; deep learning; gene transcription; receptor ... See more keywords
Lengthening the Guanidine–Aryl Linker of Phenylpyrimidinylguanidines Increases Their Potency as Inhibitors of FOXO3-Induced Gene Transcription
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c04613
Abstract: Increased FOXO3 nuclear localization is involved in neuroblastoma chemoresistance and tumor angiogenesis. Accordingly, FOXO3 inhibition is a promising strategy for boosting antitumor immune responses and suppressing FOXO3-mediated therapy resistance in cancer cells. However, no FOXO3… read more here.
Keywords: transcription; induced gene; foxo3 induced; gene transcription ... See more keywords
Hepatic pathology and altered gene transcription in a murine model of acid ceramidase deficiency
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-019-0271-4
Abstract: Farber disease (FD) is a rare lysosomal storage disorder (LSD) characterized by systemic ceramide accumulation caused by a deficiency in acid ceramidase (ACDase). In its classic form, FD manifests with painful lipogranulomatous nodules in extremities… read more here.
Keywords: gene transcription; pathology; altered gene; gene ... See more keywords
Gestational diabetes induces behavioral and brain gene transcription dysregulation in adult offspring
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-01096-7
Abstract: The etiology of Autism Spectrum Disorders (ASD) includes a strong genetic component and a complicated environmental component. Recent evidence indicates that maternal diabetes, including gestational diabetes, is associated with an increased prevalence of ASD. While… read more here.
Keywords: gestational diabetes; brain; dysregulation; gene transcription ... See more keywords
TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00307-y
Abstract: DNA double-strand breaks (DSBs) induced by abortive topoisomerase II (TOP2) activity are a potential source of genome instability and chromosome translocation. TOP2-induced DNA double-strand breaks are rejoined in part by tyrosyl-DNA phosphodiesterase 2 (TDP2)-dependent non-homologous… read more here.
Keywords: transcription; tdp2 suppresses; gene transcription; topoisomerase ... See more keywords
Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00357-2
Abstract: A new paradigm of G-protein-coupled receptor (GPCR) signaling at intracellular sites has recently emerged, but the underlying mechanisms and functional consequences are insufficiently understood. Here, we show that upon internalization in thyroid cells, endogenous TSH… read more here.
Keywords: protein; tsh receptors; local protein; gene transcription ... See more keywords
Organization and regulation of gene transcription
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1517-4
Abstract: The regulated transcription of genes determines cell identity and function. Recent structural studies have elucidated mechanisms that govern the regulation of transcription by RNA polymerases during the initiation and elongation phases. Microscopy studies have revealed… read more here.
Keywords: transcription; organization regulation; microscopy; gene transcription ... See more keywords