Multi‐Mode Antibacterial Strategies Enabled by Gene‐Transfection and Immunomodulatory Nanoparticles in 3D‐Printed Scaffolds for Synergistic Exogenous and Endogenous Treatment of Infections
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202200096
Abstract: As research on refractory Staphylococcus aureus‐related implant infection intensifies, certain challenges remain, including low antibiotic concentrations within infected areas, immune escape achieved by intracellular bacteria, myeloid‐derived suppressor cells (MDSCs) inducing regional immunosuppression, and recurrence of… read more here.
Keywords: multi mode; antibacterial strategies; mode antibacterial; gene transfection ... See more keywords
A Branched Tripeptide with an Anion‐Binding Motif as a New Delivery Carrier for Efficient Gene Transfection
Sign Up to like & getrecommendations! Published in 2019 at "ChemBioChem"
DOI: 10.1002/cbic.201800728
Abstract: Branched and dendrimeric cationic peptides have shown better transfection efficiency than linear peptides, owing to their superior capacity for inducing DNA condensation. We have designed and synthesized two analogously guanidinocarbonylpyrrole‐substituted (GCP‐substituted) branched cationic tripeptides that… read more here.
Keywords: transfection; efficient gene; branched tripeptide; tripeptide anion ... See more keywords
Construction of Bovine Serum Albumin/AIE-Based Quaternary Complexes for Efficient Gene Transfection.
Sign Up to like & getrecommendations! Published in 2019 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201800359
Abstract: High transfection efficiency and superior cell imaging are required for cationic polymers-based gene delivery system to afford high therapeutic effect but its high toxicity and unstable cell imaging are easily ignored. In this study, cationic… read more here.
Keywords: transfection; bsa; gene transfection; gene ... See more keywords
Comparison of Gene Transfection and Cytotoxicity Mechanisms of Linear Poly(amidoamine) and Branched Poly(ethyleneimine) Polyplexes
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2328-7
Abstract: PurposeThis study aimed to further explore the mechanisms behind the ability of certain linear polyamidoamines (PAAs) to transfect cells with minimal cytotoxicity.MethodsThe transfection efficiency of DNA complexed with a PAA of a molecular weight over… read more here.
Keywords: transfection; paa polyplexes; gene transfection; comparison gene ... See more keywords
Micropattern-controlled chirality of focal adhesions regulates the cytoskeletal arrangement and gene transfection of mesenchymal stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120751
Abstract: Cell chirality has been demonstrated to be important for controlling cell functions. However, it is not clear how the chirality of the extracellular microenvironment regulates cell adhesion and cytoskeletal structures and therefore affects gene transfection.… read more here.
Keywords: chirality focal; gene; gene transfection; focal adhesions ... See more keywords
Synthetic Helical Polypeptide as a Gene Transfection Enhancer.
Sign Up to like & getrecommendations! Published in 2022 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.2c00331
Abstract: The relatively low transfection efficiency limits further application of polymeric gene carriers. It is imperative to exploit a universal and simple strategy to enhance the gene transfection efficiency of polymeric gene carriers. Herein, we prepared… read more here.
Keywords: polymeric gene; gene transfection; transfection efficiency; gene ... See more keywords
A Photothermal Polymeric Platform for Efficient and Safe Gene Transfection: When Polyethylenimine Collaborates with Indocyanine Green.
Sign Up to like & getrecommendations! Published in 2024 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c10144
Abstract: Gene transfection, defined by the delivery of nucleic acids into cellular compartments, stands as a crucial procedure in gene therapy. While branched polyethylenimine (PEI) is widely regarded as the "gold standard" for nonviral vectors, its… read more here.
Keywords: pdna; transfection; transfection efficiency; indocyanine green ... See more keywords
Influence of Cell Morphology on Mesenchymal Stem Cell Transfection.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20490
Abstract: Gene transfection has broad applications in bioengineering and biomedical fields. Although many gene carrier materials and transfection methods have been developed, it remains unclear how cell morphology including cell spreading and elongation affects gene transfection.… read more here.
Keywords: cell morphology; cell; gene transfection; transfection ... See more keywords
Photothermally Activated Electrospun Nanofiber Mats for High-Efficiency Surface-Mediated Gene Transfection.
Sign Up to like & getrecommendations! Published in 2020 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b20221
Abstract: Although electrospun nanofibers have been used to deliver functional genes into cells attached to the surface of the nanofibers, yet the controllable release of genes from nanofibers and subsequent gene transfection with high efficiency remain… read more here.
Keywords: high efficiency; surface; gene transfection; transfection ... See more keywords
Supramolecular β-Sheets Stabilized Protein Nanocarriers for Drug Delivery and Gene Transfection.
Sign Up to like & getrecommendations! Published in 2017 at "ACS nano"
DOI: 10.1021/acsnano.6b08393
Abstract: Suckerin proteins, recently discovered in the sucker ring teeth of squids, represent a family of promising structural biomacromolecules that can form supramolecular networks stabilized by nanoconfined β-sheets. Exploiting this feature as well as their specific… read more here.
Keywords: drug delivery; gene; gene transfection;
Library of Cationic Polymers Composed of Polyamines and Arginine as Gene Transfection Agents
Sign Up to like & getrecommendations! Published in 2019 at "ACS Omega"
DOI: 10.1021/acsomega.8b02977
Abstract: Combinatorially synthesized materials, especially cationic polymers (CPs), with gene transfection function hold great promise in nanotechnology. However, the main limitations of the existing CPs [such as polyethylenimine (PEI), poly-l-arginine, or polyamidoamine-based dendrimers] as gene transfection… read more here.
Keywords: gene transfection; composed polyamines; gene; cationic polymers ... See more keywords