Human perforin gene variation is geographically distributed
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.344
Abstract: Deleterious mutations in PRF1 result in lethal, childhood disease, familial hemophagocytic lymphohistiocytosis type 2 (FHL 2). However, not all mutations in PRF1 are deleterious and result in FHL 2. Currently, these nondeleterious mutations are being… read more here.
Keywords: variation geographically; medicine; gene variation; human perforin ... See more keywords
P.3.005 Interactions of oxytocin receptor gene variation with behavioural inhibition and adult separation anxiety in complicated grief
Sign Up to like & getrecommendations! Published in 2018 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.12.095
Abstract: Complicated grief (CG) refers to the severe and prolonged (≥ 6 months) grief reaction following the loss of a beloved person that occurs in approximately 10 – 20% of bereaved individuals and is associated with… read more here.
Keywords: separation anxiety; adult; anxiety; complicated grief ... See more keywords
Effects of Pharmacokinetic Gene Variation on Therapeutic Drug Levels and Antidepressant Treatment Response
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DOI: 10.1055/a-1872-0613
Abstract: Introduction Pharmacogenetic testing is proposed to minimize adverse effects when considered in combination with pharmacological knowledge of the drug. As yet, limited studies in clinical settings have investigated the predictive value of pharmacokinetic (pk) gene… read more here.
Keywords: gene variation; treatment response; drug; therapeutic drug ... See more keywords
Association between RAC1 gene variation, redox homeostasis and type 2 diabetes mellitus
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DOI: 10.1111/eci.13792
Abstract: Increased production of reactive oxygen species (ROS) and oxidative stress are known to play a key role in the pathogenesis of type 2 diabetes (T2D); however, the relationship between genes encoding a multi‐subunit ROS‐generated enzyme… read more here.
Keywords: variation redox; rac1 gene; association rac1; type diabetes ... See more keywords