Biodegradable Carbon Dioxide‐Derived Non‐Viral Gene Vectors for Osteosarcoma Gene Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202201306
Abstract: Osteosarcoma often occurs in children and adolescents with high invasiveness and high mortality. Polo‐like kinase 1 (PLK1) overexpressed in most tumors promotes cancer cell proliferation and transformation. PLK1 is considered as a therapeutic target for… read more here.
Keywords: osteosarcoma; biodegradable carbon; gene vectors; carbon dioxide ... See more keywords
Structure-function relationships of nonviral gene vectors: Lessons from antimicrobial polymers.
Sign Up to like & getrecommendations! Published in 2019 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2018.12.041
Abstract: In recent years, substantial advances have been achieved in the design and synthesis of nonviral gene vectors. However, lack of effective and biocompatible vectors still remains a major challenge that hinders their application in clinical… read more here.
Keywords: gene vectors; antimicrobial polymers; function relationships; nonviral gene ... See more keywords
Rapidly Visualizing the Membrane Affinity of Gene Vectors Using Polydiacetylene-Based Allochroic Vesicles.
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DOI: 10.1021/acssensors.9b00102
Abstract: The high-throughput screening of chemically active substances has aroused widespread interest in recent years. The screening of drug carriers is usually ignored, although they interact directly with physiological barriers and target cells, and they determine… read more here.
Keywords: gene; membrane affinity; gene vectors; affinity gene ... See more keywords
Biomaterial-guided delivery of gene vectors for targeted articular cartilage repair
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DOI: 10.1038/s41584-018-0125-2
Abstract: Articular cartilage defects are prevalent and are potentially involved in the initiation of osteoarthritis, yet the lack of efficient therapeutic options to treat cartilage defects represents a substantial challenge. Molecular treatments that require the delivery… read more here.
Keywords: cartilage repair; gene vectors; articular cartilage; gene ... See more keywords
Recent advances in the development of polyethylenimine-based gene vectors for safe and efficient gene delivery
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Drug Delivery"
DOI: 10.1080/17425247.2019.1604681
Abstract: ABSTRACT Introduction Despite the great therapeutic potential of gene therapy for treating critical diseases, the clinical application is limited by lack of safe and effective gene delivery vectors. Nonviral gene vectors have attracted tremendous attention… read more here.
Keywords: gene vectors; delivery; efficient gene; gene delivery ... See more keywords