Direct posttranslational modification of astrocytic connexin 43 proteins by the general anesthetic propofol in the cerebral cortex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.142
Abstract: Propofol is widely used as a general anesthetic and is generally considered to exert its action by regulating neuronal firing via facilitation of GABAA receptors. However, accumulating evidence suggests that propofol also acts on astrocytes,… read more here.
Keywords: gap; propofol; posttranslational modification; general anesthetic ... See more keywords
Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2017.12.054
Abstract: Propofol is the most commonly used general anesthetic in humans. Our understanding of its mechanism of action has focused on its capacity to potentiate inhibitory systems in the brain. However, it is unknown whether other neural mechanisms are involved… read more here.
Keywords: trapping syntaxin1a; syntaxin1a; clinically relevant; syntaxin1a mobility ... See more keywords
General anesthetic induced differential changes in latency of auditory evoked potential in the central nucleus of inferior colliculus of mouse
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.134325
Abstract: Confirming the effect of general anesthetic on brainstem auditory evoked potential (BAEP) is important to interpret BAEP data, elucidate the neuroanatomical sites of action of general anesthetic and monitor the effect of general anesthetic. However,… read more here.
Keywords: differential changes; latency; auditory; evoked potential ... See more keywords
General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.03.022
Abstract: &NA; Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental… read more here.
Keywords: exposure; affective behaviors; anesthetic exposure; general anesthetic ... See more keywords
Dental Extractions under General Anesthesia: New Insights from Process Mining.
Sign Up to like & getrecommendations! Published in 2022 at "JDR clinical and translational research"
DOI: 10.1177/23800844221088833
Abstract: INTRODUCTION Tooth extraction under general anesthetic (GA) is a global health problem. It is expensive, high risk, and resource intensive, and its prevalence and burden should be reduced where possible. Recent innovation in data analysis… read more here.
Keywords: extraction; general anesthetic; extractions general; process mining ... See more keywords
Anesthetic Agents and Neuronal Autophagy. What We Know and What We Don't.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867324666171009123605
Abstract: BACKGROUND Ethanol is known to have both γ-Aminobutyric acid agonist and Nmethyl- D-aspartate antagonist characteristics similar to commonly used volatile anesthetic agents. Recent evidence demonstrates that autophagy can reduce the development of ethanol induced neurotoxicity.… read more here.
Keywords: neuronal autophagy; anesthetic agents; autophagy; agents neuronal ... See more keywords
GABAA Receptors in Astrocytes Are Targets for Commonly Used Intravenous and Inhalational General Anesthetic Drugs
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.802582
Abstract: Background: Perioperative neurocognitive disorders (PNDs) occur commonly in older patients after anesthesia and surgery. Treating astrocytes with general anesthetic drugs stimulates the release of soluble factors that increase the cell-surface expression and function of GABAA… read more here.
Keywords: gabaa receptors; anesthetic drugs; general anesthetic; sevoflurane ... See more keywords