Gabra6100Q allele Sprague-Dawley rats have a higher sensitivity to hypnosis induced by isoflurane and ethanol than the wild type rats
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136142
Abstract: BACKGROUND The neurobiological mechanisms underlying how general anesthetics render a patient's unconsciousness (hypnosis) remains elusive. The role of the cerebellum in hypnosis induced by general anesthetics is unknown. Gabra6100Q allele Sprague-Dawley (SD) rats have a… read more here.
Keywords: gabra6100q allele; isoflurane ethanol; hypnosis; induced isoflurane ... See more keywords
A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep
Sign Up to like & getrecommendations! Published in 2019 at "Neuron"
DOI: 10.1016/j.neuron.2019.03.033
Abstract: How general anesthesia (GA) induces loss of consciousness remains unclear, and whether diverse anesthetic drugs and sleep share a common neural pathway is unknown. Previous studies have revealed that many GA drugs inhibit neural activity… read more here.
Keywords: neuroendocrine substrate; substrate diverse; general anesthetics; common neuroendocrine ... See more keywords
General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.03.022
Abstract: &NA; Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental… read more here.
Keywords: exposure; affective behaviors; anesthetic exposure; general anesthetic ... See more keywords
Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00253
Abstract: In the present work, a series of structurally novel benzocyclobutene derivatives were identified as general anesthetics through the loss of righting reflex (LORR) experiment on mice. Our initial efforts found compound 1a with a fused… read more here.
Keywords: design synthesis; series; benzocyclobutene derivatives; general anesthetics ... See more keywords
General Anesthetics Regulate Autophagy via Modulating the Inositol 1,4,5-Trisphosphate Receptor: Implications for Dual Effects of Cytoprotection and Cytotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-11607-0
Abstract: General anesthetics are both neuroprotective and neurotoxic with unclear mechanisms. General anesthetics may control cell survival via their effects on autophagy by activation of type 1 inositol triphosphate receptor (InsP3R-1). DT40 or SH-SY5Y cells with… read more here.
Keywords: regulate autophagy; propofol; cytoprotection; anesthetics regulate ... See more keywords
Understanding the Effects of General Anesthetics on Cortical Network Activity Using Ex Vivo Preparations.
Sign Up to like & getrecommendations! Published in 2019 at "Anesthesiology"
DOI: 10.1097/aln.0000000000002554
Abstract: General anesthetics have been used to ablate consciousness during surgery for more than 150 yr. Despite significant advances in our understanding of their molecular-level pharmacologic effects, comparatively little is known about how anesthetics alter brain… read more here.
Keywords: cortical network; general anesthetics; network activity; understanding effects ... See more keywords
General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0190213
Abstract: General anesthetics are indispensable for effective clinical care. Although, the mechanism of action of general anesthetics remains controversial, lipid bilayers and proteins have been discussed as their targets. In this study, we focused on the… read more here.
Keywords: cause mitochondrial; anesthetics cause; atp; general anesthetics ... See more keywords
The Effects of General Anesthetics on Synaptic Transmission
Sign Up to like & getrecommendations! Published in 2020 at "Current Neuropharmacology"
DOI: 10.2174/1570159x18666200227125854
Abstract: General anesthetics are a class of drugs that target the central nervous system and are widely used for various medical procedures. General anesthetics produce many behavioral changes required for clinical intervention, including amnesia, hypnosis, analgesia,… read more here.
Keywords: anesthetics synaptic; molecular targets; general anesthetics; synaptic transmission ... See more keywords
Bottom-Up and Top-Down Mechanisms of General Anesthetics Modulate Different Dimensions of Consciousness
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2017.00044
Abstract: There has been controversy regarding the precise mechanisms of anesthetic-induced unconsciousness, with two salient approaches that have emerged within systems neuroscience. One prominent approach is the “bottom up” paradigm, which argues that anesthetics suppress consciousness… read more here.
Keywords: bottom top; anesthetics modulate; top mechanisms; mechanisms general ... See more keywords
Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Neural Circuits"
DOI: 10.3389/fncir.2018.00050
Abstract: It has been argued that general anesthetics suppress the level of consciousness, or the contents of consciousness, or both. The distinction between level and content is important because, in addition to clarifying the mechanisms of… read more here.
Keywords: apical function; general anesthetics; anesthetics affect; pyramidal cells ... See more keywords
Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity?
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031128
Abstract: Since its invention, general anesthesia has been an indispensable component of modern surgery. While traditionally considered safe and beneficial in many pathological settings, hundreds of preclinical studies in various animal species have raised concerns about… read more here.
Keywords: anesthesia induced; protective strategies; developmental neurotoxicity; neurotoxicity ... See more keywords