A General Diastereoselective Strategy for Both cis- and trans-2,6-Disubstituted Tetrahydropyrans: Formal Total Synthesis of (+)-Muconin.
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DOI: 10.1021/acs.orglett.8b03053
Abstract: A protocol for general diastereoselective tandem dihydroxylation followed by SN2 cyclization was developed for the convenient and efficient synthesis of cis- and trans-2,6-disubstituted tetrahydropyrans from ζ-mesyloxy α,β-unsaturated esters. The application of this novel method was… read more here.
Keywords: synthesis muconin; general diastereoselective; trans disubstituted; disubstituted tetrahydropyrans ... See more keywords