Evolution of a General RNA-Cleaving FANA Enzyme
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DOI: 10.1038/s41467-018-07611-1
Abstract: The isolation of synthetic genetic polymers (XNAs) with catalytic activity demonstrates that catalysis is not limited to natural biopolymers, but it remains unknown whether such systems can achieve robust catalysis with Michaelis-Menten kinetics. Here, we… read more here.
Keywords: rna; general rna; evolution general; rna cleaving ... See more keywords
Therapeutic Targeting of the General RNA Polymerase II Transcription Machinery
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DOI: 10.3390/ijms21093354
Abstract: Inhibitors targeting the general RNA polymerase II (RNAPII) transcription machinery are candidate therapeutics in cancer and other complex diseases. Here, we review the molecular targets and mechanisms of action of these compounds, framing them within… read more here.
Keywords: transcription; transcription machinery; rna polymerase; general rna ... See more keywords