Responsive neurostimulation targeting anterior thalamic nucleus in generalized epilepsy
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DOI: 10.1002/acn3.50858
Abstract: Responsive neurostimulation (RNS) has emerged as an adjunctive treatment modality for patients with intractable focal epilepsy who are not surgical candidates or have more than one ictal onset focus. We report a 34‐year‐old patient with… read more here.
Keywords: neurostimulation targeting; anterior thalamic; responsive neurostimulation; generalized epilepsy ... See more keywords
Extreme late onset of genetic generalized epilepsy in older adults and the elderly: A cohort study and literature review
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DOI: 10.1002/epi4.12671
Abstract: Rare case reports describe genetic generalized epilepsy (GGE) starting de novo in people ≥50 years of age (older adults and the elderly). We aimed to provide comprehensive detail of electro‐clinical findings of this extremely late‐onset GGE… read more here.
Keywords: adults elderly; older adults; epilepsy; generalized epilepsy ... See more keywords
Dynamic functional network connectivity in idiopathic generalized epilepsy with generalized tonic–clonic seizure
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DOI: 10.1002/hbm.23430
Abstract: Idiopathic generalized epilepsy (IGE) has been linked with disrupted intra‐network connectivity of multiple resting‐state networks (RSNs); however, whether impairment is present in inter‐network interactions between RSNs, remains largely unclear. Here, 50 patients with IGE characterized… read more here.
Keywords: state; idiopathic generalized; network; connectivity ... See more keywords
Novel mutation of SCN9A gene causing generalized epilepsy with febrile seizures plus in a Chinese family
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DOI: 10.1007/s10072-020-04284-x
Abstract: Generalized epilepsy with febrile seizures plus (GEFS+) is a complex familial epilepsy syndrome. It is mainly caused by mutations in SCN1A gene, encoding type 1 voltage-gated sodium channel α-subunit (NaV1.1), and GABRA1 gene, encoding the… read more here.
Keywords: chinese family; gene; generalized epilepsy; mutation ... See more keywords
Childhood-onset generalized epilepsy in Bainbridge-Ropers syndrome
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DOI: 10.1016/j.eplepsyres.2018.01.014
Abstract: Bainbridge-Ropers syndrome is a genetic syndrome caused by heterozygous loss-of-function pathogenic variants in ASXL3, which encodes a protein involved in transcriptional regulation. Affected individuals have multiple abnormalities including developmental impairment, hypotonia and characteristic facial features.… read more here.
Keywords: onset generalized; bainbridge ropers; generalized epilepsy; ropers syndrome ... See more keywords
The clinical spectrum of familial and sporadic idiopathic generalized epilepsy
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DOI: 10.1016/j.eplepsyres.2020.106374
Abstract: OBJECTIVE Although the genetic origin of Idiopathic/Genetic Generalized Epilepsy (IGE) is hardly disputed, only a minority of patients show Mendelian inheritance. We here questioned if clinical characteristics like long-term outcome and treatment response differ between… read more here.
Keywords: treatment response; ige; treatment; generalized epilepsy ... See more keywords
Phenotypic analysis of 303 multiplex families with common epilepsies
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DOI: 10.1093/brain/awx129
Abstract: Gene identification in epilepsy has mainly been limited to large families segregating genes of major effect and de novo mutations in epileptic encephalopathies. Many families that present with common non-acquired focal epilepsies and genetic generalized… read more here.
Keywords: epilepsy; common epilepsies; multiplex families; familial focal ... See more keywords
Responsive Neurostimulation of the Thalamus Improves Seizure Control in Idiopathic Generalized Epilepsy: A Case Report.
Sign Up to like & getrecommendations! Published in 2020 at "Neurosurgery"
DOI: 10.1093/neuros/nyaa001
Abstract: BACKGROUND AND IMPORTANCE At least 25% of patients with idiopathic generalized epilepsy do not obtain adequate seizure control with medication. This report describes the first use of responsive neurostimulation (RNS), bilaterally targeting the centromedian/ventrolateral (CM/VL)… read more here.
Keywords: epilepsy; idiopathic generalized; responsive neurostimulation; seizure control ... See more keywords
Can EEG Differentiate Among Syndromes in Genetic Generalized Epilepsy?
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DOI: 10.1097/wnp.0000000000000358
Abstract: Purpose: To evaluate EEG differences among syndromes in genetic generalized epilepsy based on quantified data. Methods: Twenty-four-hour ambulatory EEGs were recorded in consecutive patients diagnosed with genetic generalized epilepsy. All epileptiform EEG abnormalities were quantified… read more here.
Keywords: epilepsy; among syndromes; density; generalized epilepsy ... See more keywords
Combined electrophysiological and morphological phenotypes in patients with genetic generalized epilepsy and their healthy siblings
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DOI: 10.1111/epi.17258
Abstract: Genetic generalized epilepsy (GGE) is characterized by aberrant neuronal dynamics and subtle structural alterations. We evaluated whether a combination of magnetic and electrical neuronal signals and cortical thickness would provide complementary information about network pathology… read more here.
Keywords: healthy siblings; electrophysiological morphological; combined electrophysiological; generalized epilepsy ... See more keywords
Neurostimulation in generalized epilepsy: A systematic review and meta‐analysis
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DOI: 10.1111/epi.17524
Abstract: There are three neurostimulation devices available to treat generalized epilepsy: vagus nerve stimulation (VNS), deep brain stimulation (DBS), and responsive neurostimulation (RNS). However, the choice between them is unclear due to lack of head‐to‐head comparisons.… read more here.
Keywords: neurostimulation generalized; generalized epilepsy; meta analysis; neurostimulation ... See more keywords