gem-Halofluorocyclopropanes via [2 + 1] Cycloadditions of In Situ Generated CFX Carbene with Alkenes.
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DOI: 10.1021/acs.orglett.2c02126
Abstract: An efficient and operationally simple synthesis of gem-bromofluorocyclopropanes under mild conditions has been developed. The method employs ethyl dibromofluoroacetate (EDBFA) as an accessible and inexpensive source of the bromofluorocarbene (:CFBr) intermediate. The protocol provides the… read more here.
Keywords: halofluorocyclopropanes via; via cycloadditions; situ generated; generated cfx ... See more keywords