Mechanism of O2 Activation and Cysteine Oxidation by the Unusual Mononuclear Cu(I) Active Site of the Formylglycine-Generating Enzyme
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DOI: 10.1021/acscentsci.5c00183
Abstract: The formylglycine-generating enzyme (FGE) catalyzes the selective oxidation of a peptidyl-cysteine to form formylglycine, a critical cotranslational modification for type I sulfatase activation and a useful bioconjugation handle. Previous studies have shown that the substrate… read more here.
Keywords: formylglycine generating; generating enzyme; unusual mononuclear; site ... See more keywords
The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
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DOI: 10.1039/d2ra03379h
Abstract: The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide… read more here.
Keywords: effects mycobacterium; generating enzyme; formylglycine generating; potential antibacterial ... See more keywords