Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23482-4
Abstract: Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs, and various inhibitors have been reported in the literature. However, none of… read more here.
Keywords: anti inflammatory; generation anti; mpges inhibitors; wild type ... See more keywords
Generation of anti-human TIM-3 monoclonal antibody for cancer immunotherapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e15135
Abstract: e15135Background: Many clinical trials show that immunotherapy become one of effective strategy in cancer treatment. The benefits of PD-1 and CTLA-4 have revealed the huge success in different type... read more here.
Keywords: generation anti; tim monoclonal; anti human; cancer ... See more keywords
Naxitamab, a new generation anti-GD2 monoclonal antibody (mAb) for treatment of relapsed/refractory high-risk neuroblastoma (HR-NB).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2020.38.15_suppl.10543
Abstract: 10543Background: NB is a rare cancer but represents the most common extracranial solid tumor of childhood. Most HR-NB patients present with or develop metastatic disease typically in bone or bone m... read more here.
Keywords: new generation; generation anti; gd2 monoclonal; naxitamab new ... See more keywords
Novel Nanotherapeutics as Next-generation Anti-infective agents: Current Trends and Future Prospectives.
Sign Up to like & getrecommendations! Published in 2019 at "Current drug discovery technologies"
DOI: 10.2174/1570163816666190715120708
Abstract: With the ever-increasing population and improvement in the healthcare system in the 21st century, the incidence of chronic microbial infections and associated health disorders also increased at a striking pace. The ability of pathogenic microorganisms… read more here.
Keywords: generation anti; microbial infections; anti infective; nanotherapeutics next ... See more keywords
Nucleoside Di- and Triphosphates as a New Generation of Anti-HIV Pronucleotides. Chemical and Biological Aspects
Sign Up to like & getrecommendations! Published in 2021 at "Applied Sciences"
DOI: 10.3390/app11052248
Abstract: This review provides a short account of the chemical synthesis of nucleoside di- and triphosphates on a historical background, together with the use of this class of compounds as potential pronucleotides in anti-HIV therapy. read more here.
Keywords: anti hiv; triphosphates new; new generation; generation anti ... See more keywords