Next-Generation CAR T-cell Therapies.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-21-1683
Abstract: SUMMARY CD19- and B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T cells have enabled unprecedented responses in a subset of refractory patients with B-cell and plasma cell malignancies, leading to their approval by the… read more here.
Keywords: cell therapies; generation car; next generation; cell ... See more keywords
Next-Generation CAR T Cells Counter Exhaustion.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nb2019-146
Abstract: A new model for studying T-cell exhaustion in human cells has enabled scientists to discover a transcription factor that, when overexpressed, helps make chimeric antigen receptor T cells resistant to this mechanism of immune failure.… read more here.
Keywords: cells counter; generation car; counter exhaustion; next generation ... See more keywords
Towards the Next Generation CAR T Cells with TEGs: In Vivo Efficacy — Toxicity Profile in Xenografts of Primary Human AML Disease and Healthy Bone Marrow
Sign Up to like & getrecommendations! Published in 2017 at "Blood"
DOI: 10.1182/blood.v130.suppl_1.3336.3336
Abstract: T.S. and I.J.G. contributed equally Background γδT cells mediate essential cancer immune surveillance by sensing transformation-dependent metabolic changes through their γδT cell receptors (TCRs). This process is independent ofMHC-restricted antigen presentation, making these innate-like receptors… read more here.
Keywords: generation car; efficacy; toxicity; blood ... See more keywords
Secretory co-factors in next-generation cellular therapies for cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.907022
Abstract: Since chimeric antigen receptor (CAR) T-cell therapies for hematologic malignancies were approved by the U.S. Food and Drug Administration, numerous “next-generation” CAR T cells have been developed to improve their safety, efficacy, and applicability. Although… read more here.
Keywords: generation car; car; next generation; car cells ... See more keywords