Third-generation CDK inhibitors: A review on the synthesis and binding modes of Palbociclib, Ribociclib and Abemaciclib.
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DOI: 10.1016/j.ejmech.2019.03.064
Abstract: The role of cyclin-dependent kinases (CDKs) in regulating the transition of cell cycle steps makes this class of enzymes a suitable target for cancer therapy. Three different generations of CDKs inhibitors have been developed so… read more here.
Keywords: palbociclib ribociclib; ribociclib abemaciclib; chemistry; generation cdk ... See more keywords