Screening for the Next-Generation T Cell Therapies.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer cell"
DOI: 10.1016/j.ccell.2020.04.009
Abstract: In a recently published Cell paper, Roth et al. report a CRISPR-based platform for developing T cell therapies that strategically combine a tumor-specific TCR with novel protein factors that potentiate antitumor function. read more here.
Keywords: cell therapies; cell; generation cell; screening next ... See more keywords
Abstract 6508: Eclipse, an automated CRISPR platform for the large-scale generation of cell models
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-6508
Abstract: Major advances in gene editing using CRISPR have improved accessibility for the creation of disease relevant in vitro models, allowing researchers to readily interrogate oncogenic driver mutations and elucidate novel targets to overcome challenges within… read more here.
Keywords: cell; platform; generation cell; cell models ... See more keywords
Next-generation cell therapies: the emerging role of CAR-NK cells.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020002547
Abstract: T cells engineered with chimeric antigen receptors (CARs) have revolutionized the field of cell therapy and changed the paradigm of treatment for many patients with relapsed or refractory B-cell malignancies. Despite this progress, there are… read more here.
Keywords: cell therapies; therapies emerging; generation cell; next generation ... See more keywords
Convergence or divergence: next frontiers toward globalization of current- and next-generation cell and gene therapies.
Sign Up to like & getrecommendations! Published in 2022 at "Regenerative medicine"
DOI: 10.2217/rme-2021-0177
Abstract: The last decades have seen a massive transformation in the field of advanced therapies, culminating in the marketing approval of different cutting-edge gene, cell- and tissue engineering-based therapies across different regions of the world. Although… read more here.
Keywords: generation cell; next generation; cell gene; gene ... See more keywords
NOX Dependent ROS Generation and Cell Metabolism
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032086
Abstract: Reactive oxygen species (ROS) represent a group of high reactive molecules with dualistic natures since they can induce cytotoxicity or regulate cellular physiology. Among the ROS, the superoxide anion radical (O2·−) is a key redox… read more here.
Keywords: metabolism; cell metabolism; generation cell; dependent ros ... See more keywords