Abstract LB328: Discovery & characterization of a next-generation FGFR4 inhibitor overcoming resistant mutations
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DOI: 10.1158/1538-7445.am2023-lb328
Abstract: Introduction: Aberrant activation of FGF19-FGFR4 signaling pathway plays an essential role in the tumorigenesis of Hepatocellular carcinoma (HCC) and FGFR4 inhibitors have shown preliminary efficacy in recent clinical trials for patients with FGF19 overexpression. However,… read more here.
Keywords: fgfr4; generation fgfr4; generation; next generation ... See more keywords