Next-Generation Heterocyclic Electrophiles as Small-Molecule Covalent MurA Inhibitors
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DOI: 10.3390/ph15121484
Abstract: Heterocyclic electrophiles as small covalent fragments showed promising inhibitory activity on the antibacterial target MurA (UDP-N-acetylglucosamine 1-carboxyvinyltransferase, EC:2.5.1.7). Here, we report the second generation of heterocyclic electrophiles: the quaternized analogue of the heterocyclic covalent fragment… read more here.
Keywords: heterocyclic electrophiles; generation heterocyclic; electrophiles small; covalent ... See more keywords