Generation of a homozygous CRISPR/Cas9-mediated knockout human iPSC line for the STUB1 locus.
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DOI: 10.1016/j.scr.2018.101378
Abstract: STUB1/CHIP is a central component of cellular protein homeostasis and interacts with key proteins involved in the pathogenesis of many neurodegenerative diseases. Missense and truncating mutations in STUB1 lead to SCAR16. For ideal in vitro… read more here.
Keywords: line; homozygous crispr; generation homozygous; crispr cas9 ... See more keywords