Research progress of mTOR inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112820
Abstract: Mammalian target of rapamycin (mTOR) is a highly conserved Serine/Threonine (Ser/Thr) protein kinase, which belongs to phosphatidylinositol-3-kinase-related kinase (PIKK) protein family. mTOR exists as two types of protein complex: mTORC1 and mTORC2, which act as… read more here.
Keywords: mtor inhibitors; mtor; structure; second generation ... See more keywords
Abstract IA25: Third-generation inhibitors of mTOR
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DOI: 10.1158/1538-7445.transcontrol16-ia25
Abstract: Precision medicines exert selective pressure on tumor cells that leads to the preferential growth of resistant subpopulations, necessitating the development of next-generation therapies to treat the evolving cancer. The PIK3CA–AKT–mTOR pathway is one of the… read more here.
Keywords: generation; generation inhibitors; mtor; third generation ... See more keywords