bootRanges: flexible generation of null sets of genomic ranges for hypothesis testing
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1101/2022.09.02.506382
Abstract: bootRanges provides fast functions for generation of bootstrapped genomic ranges representing the null sets in enrichment analysis. We show that shuffling or permutation schemes may result in overly narrow test statistics null distributions, while creating… read more here.
Keywords: null sets; bootranges flexible; genomic ranges; flexible generation ... See more keywords
Targeted Generation of Null Mutants in ZmGDIα Confers Resistance against Maize Rough Dwarf Disease without Agronomic Penalty.
Sign Up to like & getrecommendations! Published in 2022 at "Plant biotechnology journal"
DOI: 10.1111/pbi.13793
Abstract: In summary, our data indicate that both null mutants generated through CRISPR/Cas9 editing exhibit stronger resistance against MRDD than the natural ZmGDIα-hel allele. Our study also alleviates any concerns about the possible agronomic penalty associated… read more here.
Keywords: agronomic penalty; null mutants; targeted generation; generation null ... See more keywords
A novel SNV on a previously reported hybrid RHCE background is responsible for an Rh haplotype potentially involved in the generation of an Rh null phenotype
Sign Up to like & getrecommendations! Published in 2022 at "Transfusion"
DOI: 10.1111/trf.17126
Abstract: More than 180 RHCE alleles have been reported so far including approximately 30 null variants. In some cases, when one RHCE null allele is present, an incorrect antigen zygosity is assumed, which may lead to… read more here.
Keywords: involved generation; haplotype potentially; null phenotype; potentially involved ... See more keywords