Enhancing radiation response by a second-generation TRAIL receptor agonist using a new in vitro organoid model system
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Translational Radiation Oncology"
DOI: 10.1016/j.ctro.2020.05.012
Abstract: Highlights • We evaluated the effect of the second-generation TRAIL receptor agonist APG-880 on radiation-induced cytotoxicity.• The combined effect was studied in short-term and long-term cytotoxicity assays in established CRC cell lines, and tumor organoids… read more here.
Keywords: receptor agonist; trail receptor; effect; second generation ... See more keywords
Functional genomic identification of predictors of sensitivity and mechanisms of resistance to multivalent 2nd generation TRAIL-R2 agonists.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular cancer therapeutics"
DOI: 10.1158/1535-7163.mct-21-0532
Abstract: Multivalent second-generation TRAIL-R2 agonists are currently in late pre-clinical development and early clinical trials. Herein, we use a representative 2nd generation agent, MEDI3039, to address two major clinical challenges facing these agents: lack of predictive… read more here.
Keywords: generation; caspase; trail agonists; resistance ... See more keywords