The Genes of Life and Death: A Potential Role for Placental‐Specific Genes in Cancer
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201700091
Abstract: The placenta invades the adjacent uterus and controls the maternal immune system, like a cancer invades surrounding organs and suppresses the local immune response. Intriguingly, placental and cancer cells are globally hypomethylated and share an… read more here.
Keywords: cancer; life death; genes life; genes cancer ... See more keywords
Role of T‐box genes in cancer, epithelial‐mesenchymal transition, and cancer stem cells
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DOI: 10.1002/jcb.30188
Abstract: Sharing a common DNA binding motif called T‐box, transcription factor T‐box gene family controls embryonic development and is also involved in cancer progression and metastasis. Cancer metastasis shows therapy resistance and involves complex processes. Among… read more here.
Keywords: cancer; mesenchymal transition; genes cancer; box genes ... See more keywords
Targeting CDK9 Reactivates Epigenetically Silenced Genes in Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.09.051
Abstract: Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through RNAPII pause release. We now report that CDK9 is also essential for maintaining gene silencing at heterochromatic loci. Through a live cell drug screen with genetic confirmation,… read more here.
Keywords: reactivates epigenetically; cdk9; genes cancer; cancer ... See more keywords