Candidate modifier genes for immune function in 22q11.2 deletion syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1057
Abstract: The 22q11.2 deletion syndrome (22q11.2DS) is the most common contiguous microdeletion affecting humans and exhibits extreme phenotypic heterogeneity. Patients can manifest any combination of comorbidities including congenital heart disease, hypoparathyroidism, cleft palate, kidney abnormalities, neurodevelopmental… read more here.
Keywords: deletion syndrome; candidate modifier; genes immune; modifier genes ... See more keywords
Enhanced antitumor efficacy of glutathione-responsive chitosan based nanoparticles through co-delivery of chemotherapeutics, genes, and immune agents.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2021.118384
Abstract: To achieve the co-delivery of chemotherapeutic drugs, genes, and immune agents in a single nanoparticulate system, p-mercaptobenzoic acid-grafted N, N, N-trimethyl chitosan nanoparticles (MT NPs) were successfully synthesized. Paclitaxel (PTX) was encapsulated into the hydrophobic… read more here.
Keywords: immune agents; delivery; enhanced antitumor; chitosan based ... See more keywords
Decoding marker genes and immune landscape of unstable carotid plaques from cellular senescence
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78251-3
Abstract: Recently, cellular senescence-induced unstable carotid plaques have gained increasing attention. In this study, we utilized bioinformatics and machine learning methods to investigate the correlation between cellular senescence and the pathological mechanisms of unstable carotid plaques.… read more here.
Keywords: senescence; carotid plaques; cellular senescence; genes immune ... See more keywords
Exploration and validation of signature genes and immune associations in septic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Hypertension"
DOI: 10.1080/10641963.2024.2302570
Abstract: ABSTRACT An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in septic cardiomyopathy. By… read more here.
Keywords: exploration validation; septic cardiomyopathy; signature genes; genes immune ... See more keywords
Potential diagnostic markers and therapeutic targets for periodontitis and Alzheimer's disease based on bioinformatics analysis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of periodontal research"
DOI: 10.1111/jre.13220
Abstract: BACKGROUND AND OBJECTIVE As a chronic inflammatory disease, periodontitis threatens oral health and is a risk factor for Alzheimer's disease (AD). There is growing evidence that these two diseases are closely related. However, current research… read more here.
Keywords: therapeutic targets; alzheimer disease; disease; common genes ... See more keywords
Identification of Key Genes and Immune Infiltrate in Nonalcoholic Steatohepatitis: A Bioinformatic Analysis
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/7561645
Abstract: Background Nonalcoholic steatohepatitis (NASH) can progress to cirrhosis and hepatic carcinoma and is closely associated with changes in the neurological environment. The discovery of new biomarkers would aid in the treatment of NASH. Methods Data… read more here.
Keywords: nonalcoholic steatohepatitis; analysis; genes immune; key genes ... See more keywords
CMTM3 as a Potential New Immune Checkpoint Regulator
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/2103515
Abstract: Objectives To evaluate the role of CKLF-like MARVEL transmembrane domain containing 3 (CMTM3) in tumor microenvironment and cancer immunotherapy and explore its potential mechanism. Method The cancer genome map was obtained from the UCSC Xena… read more here.
Keywords: cmtm3 potential; cmtm3; genes immune; cmtm3 expression ... See more keywords
Identification and Analysis of Hub Genes and Immune Cells Associated with the Formation of Acute Aortic Dissection
Sign Up to like & getrecommendations! Published in 2023 at "Computational and Mathematical Methods in Medicine"
DOI: 10.1155/2023/8072369
Abstract: Background Acute type A aortic dissection (AAD) is a catastrophic disease with high mortality, but the pathogenesis has not been fully elucidated. This study is aimed at identifying hub genes and immune cells associated with… read more here.
Keywords: hub genes; dna damage; genes immune; analysis ... See more keywords
Characteristic genes and immune landscape of interstitial cystitis
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0320249
Abstract: Background Interstitial cystitis (IC) was still a disease with the exclusive diagnosis and lacked an effective gold standard. It was of great significance to find diagnostic markers for IC. Our study was aimed to screen… read more here.
Keywords: interstitial cystitis; immune landscape; genes immune; characteristic genes ... See more keywords
Characterization of Immune-Related Genes and Immune Infiltration Features in Epilepsy by Multi-Transcriptome Data
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s360743
Abstract: Background Epilepsy encompasses a group of heterogeneous brain diseases that afflict about 1% of the world’s population. Accumulating evidence shows that the immune system plays a key role in epileptogenesis. Nevertheless, the immune-related mechanisms remain… read more here.
Keywords: infiltration; immune related; genes immune; epilepsy ... See more keywords
Exploration and Validation of Key Genes and Immune Infiltration in Alcoholic Hepatitis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s514515
Abstract: Objective Apart from alcohol abstinence and glucocorticoids, there is still no effective treatment to improve alcoholic hepatitis, and the specific mechanism of its pathogenesis is still unclear. Methods We screened the differential genes in GEO… read more here.
Keywords: alcoholic hepatitis; genes immune; analysis; hepatitis ... See more keywords