Searching Novel Clock Genes Using RNAi-Based Screening.
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DOI: 10.1007/978-1-0716-0381-9_8
Abstract: RNA interference (RNAi) allows for the selective downregulation of gene expression by neutralizing targeted mRNA molecules and has frequently been used in high-throughput screening endeavors. Here, we describe a protocol for the highly parallel RNAi-mediated… read more here.
Keywords: searching novel; rnai; using rnai; novel clock ... See more keywords
Locating potentially lethal genes using the abnormal distributions of genotypes
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DOI: 10.1038/s41598-019-47076-w
Abstract: Genes are the basic functional units of heredity. Differences in genes can lead to various congenital physical conditions. One kind of these differences is caused by genetic variations named single nucleotide polymorphisms (SNPs). An SNP… read more here.
Keywords: distributions genotypes; locating potentially; abnormal distributions; lethal genes ... See more keywords
Identification of rheumatoid arthritis causal genes using functional genomics
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DOI: 10.1111/sji.12753
Abstract: Over the past decade, genome‐wide association studies have contributed a wealth of knowledge to our understanding of polygenic disorders such as rheumatoid arthritis. As the size of sample cohorts has improved so too have the… read more here.
Keywords: arthritis causal; identification rheumatoid; rheumatoid arthritis; arthritis ... See more keywords