Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202104491
Abstract: Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 (NEK2) is upregulated in multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood.… read more here.
Keywords: aberrations interaction; interaction nek2; multiple myeloma; nek2 tp53 ... See more keywords
Multifocal primary neuroblastoma tumor heterogeneity in siblings with co‐occurring PHOX2B and NF1 genetic aberrations
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.1002/gcc.22809
Abstract: Neuroblastoma, the most common extracranial solid tumor of childhood, can present in multiple primary sites, but the extent of genetic heterogeneity among tumor foci, as well as the presence or absence of common oncogenic drivers,… read more here.
Keywords: genetic aberrations; heterogeneity; phox2b nf1; neuroblastoma ... See more keywords
Genomic Instability of iPSCs and Challenges in Their Clinical Applications.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-31206-0_2
Abstract: Generation of human-induced pluripotent stem cells (iPSCs) from somatic cells has opened the possibility to design novel therapeutic approaches. In 2014, the first-in-human clinical trial of iPSC-based therapy was conducted. However, the transplantation for the… read more here.
Keywords: ipscs challenges; genetic aberrations; genomic instability; instability ipscs ... See more keywords
Whole Transcriptome RNA Sequencing As a Comprehensive Diagnostic Tool for Acute Myeloid Leukemia
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DOI: 10.1182/blood-2018-99-111115
Abstract: Introduction Acute myeloid leukemia (AML) is characterized by uncontrolled proliferation of malignant myeloid progenitor cells in the bone marrow that are arrested in differentiation. In AML, genetic aberrations often involve the same genes and play… read more here.
Keywords: classification; genetic aberrations; classification aml; myeloid ... See more keywords
Combined impact of lipidomic and genetic aberrations on clinical outcomes in metastatic castration-resistant prostate cancer
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DOI: 10.1186/s12916-022-02298-0
Abstract: Both changes in circulating lipids represented by a validated poor prognostic 3-lipid signature (3LS) and somatic tumour genetic aberrations are individually associated with worse clinical outcomes in men with metastatic castration-resistant prostate cancer (mCRPC). A… read more here.
Keywords: tp53 rb1; cancer; clinical outcomes; genetic aberrations ... See more keywords
Presence of genetic aberrations in patients with brain metastases from non-small cell lung cancer (NSCLC) and clinical outcomes.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.e20604
Abstract: e20604Background: Historically, survival in patients (pts) with NSCLC brain metastases (BM) is poor, however, improved systemic therapies are now available including targeted therapies and immunoth... read more here.
Keywords: brain metastases; genetic aberrations; patients brain; presence genetic ... See more keywords
Molecularly Targeted Therapy towards Genetic Alterations in Advanced Bladder Cancer
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DOI: 10.3390/cancers14071795
Abstract: Simple Summary In recent years, there have been several advances in the care of advanced bladder cancer, highlighted by the addition of immune checkpoint inhibitors to the care of advanced disease. Despite these advances, there… read more here.
Keywords: bladder; genetic alterations; genetic aberrations; advanced bladder ... See more keywords
Determination of genetic aberrations and novel transcripts involved in the pathogenesis of oligodendroglioma using array comparative genomic hybridization and next generation sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Oncology Letters"
DOI: 10.3892/ol.2018.9811
Abstract: The aim of the present study was to determine the genetic aberrations and novel transcripts, particularly the fusion transcripts, involved in the pathogenesis of low-grade and anaplastic oligodendroglioma. In the present study, tissue samples were… read more here.
Keywords: genetic aberrations; genomic hybridization; oligodendroglioma; aberrations novel ... See more keywords