Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice
Sign Up to like & getrecommendations! Published in 2021 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.121.316034
Abstract: Supplemental Digital Content is available in the text. Objective: Atherosclerosis is a key component of cardiovascular diseases. We set out to study here whether genetic ablation of P4H-TM (transmembrane prolyl 4-hydroxylase) could protect against atherosclerosis… read more here.
Keywords: genetic ablation; prolyl hydroxylase; prolyl; transmembrane prolyl ... See more keywords
Genetic ablation of metabotropic glutamate receptor 5 in rats results in an autism-like behavioral phenotype
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DOI: 10.1371/journal.pone.0275937
Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in communication, and social skills, as well as repetitive and/or restrictive interests and behaviors. The severity of ASD varies from mild to severe, drastically… read more here.
Keywords: phenotype; glutamate receptor; metabotropic glutamate; genetic ablation ... See more keywords
The Pathological Role of Astrocytic MAOB in Parkinsonism Revealed by Genetic Ablation and Over-expression of MAOB
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DOI: 10.5607/en21007
Abstract: The cause of Parkinson’s disease has been traditionally believed to be the dopaminergic neuronal death in the substantia nigra pars compacta (SNpc). This traditional view has been recently challenged by the proposal that reactive astrocytes… read more here.
Keywords: parkinsonian motor; genetic ablation; astrocytic maob; motor symptoms ... See more keywords