Expansion of the genetic code via expansion of the genetic alphabet.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.08.009
Abstract: Current methods to expand the genetic code enable site-specific incorporation of non-canonical amino acids (ncAAs) into proteins in eukaryotic and prokaryotic cells. However, current methods are limited by the number of codons possible, their orthogonality,… read more here.
Keywords: expansion genetic; genetic alphabet; genetic code; expansion ... See more keywords
Tautomeric Equilibria of Nucleobases in the Hachimoji Expanded Genetic Alphabet.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.9b01079
Abstract: Evolution has yielded biopolymers that are constructed from exactly four building blocks and are able to support Darwinian evolution. Synthetic biology aims to extend this alphabet, and we recently showed that 8-letter (hachimoji) DNA can… read more here.
Keywords: hachimoji; alphabet; expanded genetic; genetic alphabet ... See more keywords