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   Articles with "genetic alteration" as a keyword



Genetic alteration of colorectal adenoma‐carcinoma sequence among gastric adenocarcinoma and dysplastic lesions in a patient with attenuated familial adenomatous polyposis

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recommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.1348

Abstract: Familial adenomatous polyposis (FAP) is characterized by colorectal polyposis and adenocarcinoma that is frequently accompanied by extracolonic neoplasm. The risk of gastric carcinoma is increasing in Western FAP patients as well as Asian patients. read more here.

Keywords: carcinoma; familial adenomatous; genetic alteration; adenocarcinoma ... See more keywords

Genetic alteration of SLCO1B3 defines constitutional indocyanine green excretory defect in patients who underwent hepatectomy

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recommendations! Published in 2024 at "Hepatology Research"

DOI: 10.1111/hepr.14099

Abstract: Constitutional indocyanine green (ICG) excretory defects must be distinguished when assessing liver function. The absence of OATP1B3 expression due to homogenous alterations in the SLCO1B3 gene has been recently reported to induce ICG excretory defects;… read more here.

Keywords: genetic alteration; excretory; constitutional indocyanine; indocyanine green ... See more keywords

The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A

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recommendations! Published in 2019 at "PLoS ONE"

DOI: 10.1371/journal.pone.0222305

Abstract: SWItch/Sucrose NonFermentable (SWI/SNF) is a set of multi-subunits chromatin remodeling complexes, playing important roles in a variety of biological processes. Loss-of-function mutations in the genes encoding SWI/SNF subunits have been reported in more than 20%… read more here.

Keywords: oncogenic roles; spectrum swi; genetic alteration; alteration spectrum ... See more keywords

Genetic Alteration Profiling in North Macedonian Lung Cancer Patients

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recommendations! Published in 2025 at "Genes"

DOI: 10.3390/genes16101177

Abstract: Background/Objectives: Late diagnosis and inefficient treatment regimens lead to poor prognosis, with a low 5-year survival rate for both non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). New targeted therapeutic agents can be developed… read more here.

Keywords: lung cancer; cancer; alteration profiling; genetic alteration ... See more keywords
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Predictive value of tumor genetic alteration profiling for chemotherapy and EGFR-TKI treatment in advanced NSCLC

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recommendations! Published in 2020 at "Oncology Letters"

DOI: 10.3892/ol.2020.11502

Abstract: Previous studies have suggested that a variety of tumor driver genetic alterations affected the treatment efficacy of chemotherapy and epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in advanced non-small cell lung cancer (NSCLC). The… read more here.

Keywords: chemotherapy egfr; treatment; genetic alteration; egfr tki ... See more keywords