The Genetic Architecture of Major Depressive Disorder in Han Chinese Women
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Psychiatry"
DOI: 10.1001/jamapsychiatry.2016.3578
Abstract: Importance Despite the moderate, well-demonstrated heritability of major depressive disorder (MDD), there has been limited success in identifying replicable genetic risk loci, suggesting a complex genetic architecture. Research is needed to quantify the relative contribution… read more here.
Keywords: risk; etiology; mdd; genetic architecture ... See more keywords
Genetic Architecture of Stroke of Undetermined Source: Overlap with Known Stroke Etiologies and Associations with Modifiable Risk Factors
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26332
Abstract: Ischemic stroke etiology remains undetermined in 30% of cases. We explored the genetic architecture of stroke classified as undetermined to test if mechanisms and risk factors underlying large‐artery atherosclerotic (LAAS), cardioembolic (CES), and small‐vessel stroke… read more here.
Keywords: architecture stroke; stroke; genetic architecture; risk factors ... See more keywords
Functional hierarchy of the angular gyrus and its underlying genetic architecture
Sign Up to like & getrecommendations! Published in 2023 at "Human Brain Mapping"
DOI: 10.1002/hbm.26247
Abstract: The angular gyrus (AG), given its rich connectivity and its location where multisensory information converges, is a functionally and anatomically heterogeneous structure. Using the state‐of‐the‐art functional gradient approach and transcription‐neuroimaging association analysis, we sought to… read more here.
Keywords: angular gyrus; genetic architecture; underlying genetic; dominant gradient ... See more keywords
Unraveling the genetic architecture of copy number variants associated with schizophrenia and other neuropsychiatric disorders
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.23970
Abstract: Recent studies show that the complex genetic architecture of schizophrenia (SZ) is driven in part by polygenic components, or the cumulative effect of variants of small effect in many genes, as well as rare single‐locus… read more here.
Keywords: genetic architecture; number variants; copy number; neuropsychiatric disorders ... See more keywords
Genetic architecture and phenotypic landscape of SLC26A4-related hearing loss.
Sign Up to like & getrecommendations! Published in 2021 at "Human genetics"
DOI: 10.1007/s00439-021-02311-1
Abstract: Mutations of coding regions and splice sites of SLC26A4 cause Pendred syndrome and nonsyndromic recessive hearing loss DFNB4. SLC26A4 encodes pendrin, a transmembrane exchanger of anions and bases. The mutant SLC26A4 phenotype is characterized by… read more here.
Keywords: genetic architecture; slc26a4; hearing loss; pendred syndrome ... See more keywords
Neurofibromatosis Type 1 Implicates Ras Pathways in the Genetic Architecture of Neurodevelopmental Disorders
Sign Up to like & getrecommendations! Published in 2020 at "Behavior Genetics"
DOI: 10.1007/s10519-020-09991-x
Abstract: The genetic architecture of neurodevelopmental disorders is largely polygenic, non-specific, and pleiotropic. This complex genetic architecture makes the search for specific etiological mechanisms that contribute to neurodevelopmental risk more challenging. Monogenic disorders provide an opportunity… read more here.
Keywords: genetic architecture; neurofibromatosis type; architecture neurodevelopmental; neurodevelopmental disorders ... See more keywords
High-density quantitative trait locus mapping revealed genetic architecture of leaf angle and tassel size in maize
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Breeding"
DOI: 10.1007/s11032-018-0914-y
Abstract: The maize leaf angle and tassel size have close relationships with grain yield. These traits had undergone a strong selection and great morphological changes during domestication and improvement. To understand the genetic architecture of these… read more here.
Keywords: tassel size; tassel; angle tassel; leaf angle ... See more keywords
Genetic architecture related to contour feathers density in an F2 resource population via a genome-wide association study
Sign Up to like & getrecommendations! Published in 2019 at "3 Biotech"
DOI: 10.1007/s13205-019-1918-y
Abstract: The density of contour feathers is an important trait as it is closely related to heat dissipation in birds. Thus, identification of the major genes that control this trait will be useful to improve heat… read more here.
Keywords: density contour; study; density; association ... See more keywords
The genetic architecture of osteoporosis and fracture risk.
Sign Up to like & getrecommendations! Published in 2019 at "Bone"
DOI: 10.1016/j.bone.2019.04.005
Abstract: Osteoporosis and fracture risk are common complex diseases, caused by an interaction of numerous disease susceptibility genes and environmental factors. With the advances in genomic technologies, large-scale genome-wide association studies (GWAS) have been performed which… read more here.
Keywords: genetic architecture; fracture risk; osteoporosis; osteoporosis fracture ... See more keywords
Diverse Non-genetic, Allele-Specific Expression Effects Shape Genetic Architecture at the Cellular Level in the Mammalian Brain
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2017.01.033
Abstract: Interactions between genetic and epigenetic effects shape brain function, behavior, and the risk for mental illness. Random X inactivation and genomic imprinting are epigenetic allelic effects that are well known to influence genetic architecture and… read more here.
Keywords: effects shape; non genetic; allelic effects; diverse non ... See more keywords
The genetic architecture of long QT syndrome: A critical reappraisal.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in cardiovascular medicine"
DOI: 10.1016/j.tcm.2018.03.003
Abstract: Collectively, the completion of the Human Genome Project and subsequent development of high-throughput next-generation sequencing methodologies have revolutionized genomic research. However, the rapid sequencing and analysis of thousands upon thousands of human exomes and genomes… read more here.
Keywords: syndrome critical; long syndrome; architecture long; critical reappraisal ... See more keywords