Benchmarking statistical methods for analyzing parent-child dyads in genetic association studies.
Sign Up to like & getrecommendations! Published in 2022 at "Genetic epidemiology"
DOI: 10.1002/gepi.22453
Abstract: Genetic association studies of child health outcomes often employ family-based study designs. One of the most popular family-based designs is the case-parent trio design that considers the smallest possible nuclear family consisting of two parents… read more here.
Keywords: methods analyzing; parent; child; case ... See more keywords
Genetic association of FMRP targets with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00912-2
Abstract: Genes encoding the mRNA targets of fragile X mental retardation protein (FMRP) are enriched for genetic association with psychiatric disorders. However, many FMRP targets possess functions that are themselves genetically associated with psychiatric disorders, including… read more here.
Keywords: genetic association; fmrp targets; psychiatric disorders; disorder ... See more keywords
Genetic association study identified a 20 kb regulatory element in WLS associated with osteoporosis and bone mineral density in Han Chinese
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-13932-w
Abstract: Previous studies have linked the WNT pathway and human skeleton formation; therefore, genes related to WNT might contribute to the onset and development of osteoporosis. In this study, we investigated the potential genetic association of… read more here.
Keywords: genetic association; bone mineral; associated osteoporosis; study ... See more keywords
Powerful and Efficient Strategies for Genetic Association Testing of Symptom and Questionnaire Data in Psychiatric Genetic Studies
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-44046-0
Abstract: Genetic studies of psychiatric disorders often deal with phenotypes that are not directly measurable. Instead, researchers rely on multivariate symptom data from questionnaires and surveys like the PTSD Symptom Scale (PSS) and Beck Depression Inventory… read more here.
Keywords: association testing; genetic association; questionnaire data; symptom ... See more keywords
Variants of the elastin (ELN) gene and susceptibility to intracranial aneurysm: a synthesis of genetic association studies using a genetic model-free approach
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Neuroscience"
DOI: 10.1080/00207454.2016.1212027
Abstract: Background: The presence of an intracranial aneurysm (IA) is thought to have a genetic origin. The genetic association studies (GAS) that investigated the association between IA and elastin gene (ELN) variants have produced contradictory or… read more here.
Keywords: intracranial aneurysm; genetic association; association studies; eln gene ... See more keywords
STOPGAP: a database for systematic target opportunity assessment by genetic association predictions
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx274
Abstract: Summary: We developed the STOPGAP (Systematic Target OPportunity assessment by Genetic Association Predictions) database, an extensive catalog of human genetic associations mapped to effector gene candidates. STOPGAP draws on a variety of publicly available GWAS… read more here.
Keywords: genetic association; target opportunity; association; systematic target ... See more keywords
Differences in set-based tests for sparse alternatives when testing sets of outcomes compared to sets of explanatory factors in genetic association studies.
Sign Up to like & getrecommendations! Published in 2022 at "Biostatistics"
DOI: 10.1093/biostatistics/kxac036
Abstract: Set-based association tests are widely popular in genetic association settings for their ability to aggregate weak signals and reduce multiple testing burdens. In particular, a class of set-based tests including the Higher Criticism, Berk-Jones, and… read more here.
Keywords: differences set; set based; explanatory factors; based tests ... See more keywords
The genetic association between osteoprotegerin (OPG) gene polymorphisms and bone mineral density (BMD) in postmenopausal women: A meta-analysis: Erratum
Sign Up to like & getrecommendations! Published in 2019 at "Medicine"
DOI: 10.1097/md.0000000000014926
Abstract: In the article, “The genetic association between osteoprotegerin (OPG) gene polymorphisms and bone mineral density (BMD) in postmenopausal women: A meta-analysis”, which appeared in Volume 97, Issue 51 of Medicine, the affiliations for the authors… read more here.
Keywords: medicine; osteoprotegerin opg; gene polymorphisms; genetic association ... See more keywords
Synthesis of genetic association studies on autism spectrum disorders using a genetic model-free approach
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000316
Abstract: Background Autism spectrum disorder (ASD) is a clinically and genetically heterogeneous group of neurodevelopmental disorders. Despite the extensive efforts of scientists, the etiology of ASD is far from completely elucidated. In an effort to enlighten… read more here.
Keywords: autism spectrum; genetic association; model; association ... See more keywords
ELM-Based Large-Scale Genetic Association Study via Statistically Significant Pattern
Sign Up to like & getrecommendations! Published in 2019 at "IEEE Transactions on Systems, Man, and Cybernetics: Systems"
DOI: 10.1109/tsmc.2017.2720702
Abstract: Genetic association study (GAS) is a promising tool for detecting and analyzing the cause of complex diseases. The extreme learning machine (ELM) has been successfully applied in a variety of research fields. Yet, as a… read more here.
Keywords: statistically significant; significant pattern; genetic association; association study ... See more keywords
Eigenvalue significance testing for genetic association.
Sign Up to like & getrecommendations! Published in 2018 at "Biometrics"
DOI: 10.1111/biom.12767
Abstract: Genotype eigenvectors are widely used as covariates for control of spurious stratification in genetic association. Significance testing for the accompanying eigenvalues has typically been based on a standard Tracy-Widom limiting distribution for the largest eigenvalue,… read more here.
Keywords: genetic association; significance testing; eigenvalue; approach ... See more keywords