Sex Differences in Genetic Associations With Longevity
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2018.1670
Abstract: Key Points Question Are there sex differences in genetic associations with longevity? Findings In this case-control study of 2178 cases and 2299 controls who were Chinese with Han ethnicity, sex-specific genome-wide association study and sex-specific… read more here.
Keywords: genetic associations; longevity; sex differences; differences genetic ... See more keywords
17 FUMA: FUNCTIONAL MAPPING AND ANNOTATION OF GENETIC ASSOCIATIONS
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.018
Abstract: Background A main challenge in genome-wide association studies (GWAS) is to prioritize genetic variants and identify potential causal mechanisms of human diseases. Although a variety of bioinformatics tools are now available for downstream analyses of… read more here.
Keywords: genetic associations; mapping; snps; genetic variants ... See more keywords
Genetic Associations Between Executive Functions and a General Factor of Psychopathology.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Academy of Child and Adolescent Psychiatry"
DOI: 10.1016/j.jaac.2019.05.006
Abstract: OBJECTIVE Symptoms of psychopathology covary across diagnostic boundaries, and a family history of elevated symptoms for a single psychiatric disorder places an individual at heightened risk for a broad range of other psychiatric disorders. Both… read more here.
Keywords: genetic associations; risk; executive functions; cognitive abilities ... See more keywords
Genetic associations between growth traits and age at first calving in Guzera cattle using random regression models
Sign Up to like & getrecommendations! Published in 2021 at "Livestock Science"
DOI: 10.1016/j.livsci.2021.104585
Abstract: Abstract The aim of this study was to estimate genetic associations between body weight (BW), scrotal circumference (SC), and age at first calving (AFC) in Guzera cattle using random regression models. The analyses used 159,366… read more here.
Keywords: genetic associations; age; age first; guzera cattle ... See more keywords
Magical thinking as a bio-psychological developmental disposition for cognitive and affective symptoms intensity in schizotypy: Traits and genetic associations
Sign Up to like & getrecommendations! Published in 2020 at "Personality and Individual Differences"
DOI: 10.1016/j.paid.2020.110498
Abstract: Abstract Schizotypy refers to a set of heritable, continuously distributed personality traits that resemble signs and symptoms of schizophrenia in the general population. It has been argued that studying the genetic background of schizotypy may… read more here.
Keywords: magical thinking; schizotypal traits; schizotypy; genetic associations ... See more keywords
Genetic associations of protein-coding variants in human disease
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04394-w
Abstract: Genome-wide association studies (GWAS) have identified thousands of genetic variants linked to the risk of human disease. However, GWAS have so far remained largely underpowered in relation to identifying associations in the rare and low-frequency… read more here.
Keywords: genetic associations; associations protein; disease; coding variants ... See more keywords
Social and genetic associations with educational performance in a Scandinavian welfare state
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201869119
Abstract: Significance Children of highly educated parents perform better in school; this may be due to social environments or genes. Most studies do not distinguish between the two, meaning that genetic associations may confound environmental explanations… read more here.
Keywords: social genetic; welfare; genetic associations; welfare state ... See more keywords
Genetic associations between bipolar disorder and brain structural phenotypes.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebral cortex"
DOI: 10.1093/cercor/bhad014
Abstract: Patients with bipolar disorder (BD) and their first-degree relatives exhibit alterations in brain volume and cortical structure, whereas the underlying genetic mechanisms remain unclear. In this study, based on the published genome-wide association studies (GWAS),… read more here.
Keywords: structural phenotypes; brain structural; brain; genetic associations ... See more keywords
Fine-mapping genetic associations.
Sign Up to like & getrecommendations! Published in 2020 at "Human molecular genetics"
DOI: 10.1093/hmg/ddaa148
Abstract: While thousands of genetic variants have been associated with human traits, identifying the subset of those variants that are causal requires a further 'fine-mapping' step. We review the standard fine-mapping approach, which is computationally fast… read more here.
Keywords: mapping genetic; genetic associations; fine mapping;
Positive genetic associations among fitness traits support evolvability of a reef-building coral under multiple stressors.
Sign Up to like & getrecommendations! Published in 2019 at "Global change biology"
DOI: 10.1111/gcb.14764
Abstract: Climate change threatens organisms in a variety of interactive ways that requires simultaneous adaptation of multiple traits. Predicting evolutionary responses requires an understanding of the potential for interactions among stressors and the genetic variance and… read more here.
Keywords: genetic associations; multiple stressors; among fitness; building coral ... See more keywords
Genetic Associations in Four Decades of Multienvironment Trials Reveal Agronomic Trait Evolution in Common Bean
Sign Up to like & getrecommendations! Published in 2020 at "Genetics"
DOI: 10.1534/genetics.120.303038
Abstract: Multienvironment trials (METs) are widely used to assess the performance of promising crop germplasm. Though seldom designed to elucidate genetic mechanisms, MET data sets are often much larger than could be duplicated for genetic research… read more here.
Keywords: genetic associations; multienvironment trials; genetics; genomic regions ... See more keywords