Effect of genetic background on the stability of sunflower fatty acid composition in different high oleic mutations.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.8924
Abstract: BACKGROUND The effect of genetic background on the stability of fatty acid composition in sunflower near isogenic lines (NILs) carrying high-oleic Pervenets (P) or high-oleic NM1 mutations was studied. The materials were field-tested in different… read more here.
Keywords: fatty acid; genetic background; acid composition; high oleic ... See more keywords
Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart
Sign Up to like & getrecommendations! Published in 2020 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-020-00831-x
Abstract: Transient receptor potential melastatin 4 (TRPM4) cation channels act in cardiomyocytes as a negative modulator of the L-type Ca2+ current. Ubiquitous Trpm4 deletion in mice leads to an increased β-adrenergic inotropy in healthy mice as… read more here.
Keywords: cation; trpm4; genetic background; background ... See more keywords
Single blastomeres as a source of mouse embryonic stem cells: effect of genetic background, medium supplements, and signaling modulators on derivation efficiency
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Assisted Reproduction and Genetics"
DOI: 10.1007/s10815-018-1360-9
Abstract: PurposeTo assess the role of the genetic background, the culture medium supplements, and the presence of modulators of signaling pathways on mouse embryonic stem cell derivation from single blastomeres from 8-cell embryos.MethodsMice from permissive and… read more here.
Keywords: medium; genetic background; single blastomeres; derivation ... See more keywords
Disorders of sexual development with XY karyotype and female phenotype: clinical findings and genetic background in a cohort from a single centre
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Endocrinological Investigation"
DOI: 10.1007/s40618-020-01284-8
Abstract: Purpose 46, XY disorders (or differences) of sex development (DSD) are a group of clinical conditions with variable genetic background; correct diagnosis is often difficult, but it permits to optimize the management. The aim of… read more here.
Keywords: female phenotype; genetic background; development; diagnosis ... See more keywords
Sex and genetic background define the metabolic, physiologic, and molecular response to protein restriction.
Sign Up to like & getrecommendations! Published in 2022 at "Cell metabolism"
DOI: 10.1016/j.cmet.2021.12.018
Abstract: Low-protein diets promote metabolic health in humans and rodents. Despite evidence that sex and genetic background are key factors in the response to diet, most protein intake studies examine only a single strain and sex… read more here.
Keywords: response; genetic background; protein; sex ... See more keywords
The genetic background significantly impacts the severity of kidney cystic disease in the Pkd1RC/RC mouse model of autosomal dominant polycystic kidney disease.
Sign Up to like & getrecommendations! Published in 2021 at "Kidney international"
DOI: 10.1016/j.kint.2021.01.028
Abstract: Autosomal dominant polycystic kidney disease (ADPKD), primarily due to PKD1 or PKD2 mutations, causes progressive kidney cyst development and kidney failure. There is significant intrafamilial variability likely due to the genetic background and environmental/lifestyle factors;… read more here.
Keywords: kidney; genetic background; disease; pkd1rc ... See more keywords
Establishment of TUSMi003-A, an induced pluripotent stem cell (iPSC) line from a 62-year old Chinese Han patient with Alzheimer's disease with ApoE3/4 genetic background.
Sign Up to like & getrecommendations! Published in 2018 at "Stem cell research"
DOI: 10.1016/j.scr.2018.01.005
Abstract: A 62-year old Chinese Han Alzheimer's disease (AD) female patient with ApoE3/4 genetic background donated her Peripheral blood mononuclear cells (PBMC). The non-integrating episomal vector system was used to reprogrammed PBMCs with the human OKSM… read more here.
Keywords: chinese han; alzheimer disease; genetic background; apoe3 genetic ... See more keywords
Genetic background impacts vaccine-induced reduction of pneumococcal colonization.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.08.023
Abstract: Vaccination has been one of the most successful strategies to reduce morbidity and mortality caused by respiratory infections. Recent evidence suggests that differences in the host genetic background and environmental factors may contribute to heterogeneity… read more here.
Keywords: reduction; pneumococcal colonization; genetic background; colonization ... See more keywords
Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14256
Abstract: Limiting the debilitating consequences of ageing is a major medical challenge of our time. Robust pharmacological interventions that promote healthy ageing across diverse genetic backgrounds may engage conserved longevity pathways. Here we report results from… read more here.
Keywords: experimental reproducibility; longevity; background experimental; genetic background ... See more keywords
A fln-2 mutation affects lethal pathology and lifespan in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13062-z
Abstract: Differences in genetic background in model organisms can have complex effects on phenotypes of interest. We previously reported a difference in hermaphrodite lifespan between two wild-type lines widely used by C. elegans researchers (N2 hermaphrodite… read more here.
Keywords: fln mutation; show fln; genetic background; pathology ... See more keywords
Association of plasma microRNA expression with age, genetic background and functional traits in dairy cattle
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-31099-w
Abstract: A number of blood circulating microRNAs (miRNAs) are proven disease biomarkers and have been associated with ageing and longevity in multiple species. However, the role of circulating miRNAs in livestock species has not been fully… read more here.
Keywords: age; genetic background; expression; traits dairy ... See more keywords