Genomic landscape of locally advanced rectal adenocarcinoma: Comparison between before and after neoadjuvant chemoradiation and effects of genetic biomarkers on clinical outcomes and tumor response.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6169
Abstract: PURPOSE To explore genomic biomarkers in rectal cancer by performing whole-exome sequencing. MATERIALS AND METHODS Pre-chemoradiation (CRT) biopsy and post-CRT surgical specimens were obtained from 27 patients undergoing neoadjuvant CRT followed by definitive resection. Exomes… read more here.
Keywords: clinical outcomes; post crt; genetic biomarkers; crt ... See more keywords
Imaging and Genetic Biomarkers Predicting Transition to Psychosis.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2018_46
Abstract: The search for diagnostic and prognostic biomarkers in schizophrenia care and treatment is the focus of many within the research community. Longitudinal cohorts of patients presenting at elevated genetic and clinical risk have provided a… read more here.
Keywords: schizophrenia; risk; transition; high risk ... See more keywords
Discovery of Genetic Biomarkers for Alzheimer's Disease Using Adaptive Convolutional Neural Networks Ensemble and Genome-Wide Association Studies.
Sign Up to like & getrecommendations! Published in 2021 at "Interdisciplinary sciences, computational life sciences"
DOI: 10.1007/s12539-021-00470-3
Abstract: OBJECTIVE To identify candidate neuroimaging and genetic biomarkers for Alzheimer's disease (AD) and other brain disorders, especially for little-investigated brain diseases, we advocate a data-driven approach which incorporates an adaptive classifier ensemble model acquired by… read more here.
Keywords: genome wide; alzheimer disease; convolutional neural; biomarkers alzheimer ... See more keywords
Identification of genetic biomarkers in urine for early detection of prostate cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Current problems in cancer"
DOI: 10.1016/j.currproblcancer.2020.100616
Abstract: Prostate cancer screening is a challenging and vital issue in the aspects of the current tests and risk assessments. Prostate cancer risk assessments are currently carried out by using blood, urine and tissue biomarkers with… read more here.
Keywords: identification genetic; genetic biomarkers; cancer identification; prostate cancer ... See more keywords
LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Glaucoma"
DOI: 10.1097/ijg.0000000000000915
Abstract: An agnostic high throughput search of the genome revealed a robust association between LOXL1 genetic polymorphisms and exfoliation syndrome (XFS), a discovery that likely would not have been possible with candidate or family-based gene search… read more here.
Keywords: exfoliation syndrome; loxl1 polymorphisms; biomarkers presage; polymorphisms genetic ... See more keywords
Genetic Biomarkers and Their Clinical Implications in B-Cell Acute Lymphoblastic Leukemia in Children
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23052755
Abstract: Acute lymphoblastic leukemia (ALL) is a heterogeneous group of hematologic malignancies characterized by abnormal proliferation of immature lymphoid cells. It is the most commonly diagnosed childhood cancer with an almost 80% cure rate. Despite favorable… read more here.
Keywords: clinical implications; genetic biomarkers; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Genetic Biomarkers of Metabolic Detoxification for Personalized Lifestyle Medicine
Sign Up to like & getrecommendations! Published in 2022 at "Nutrients"
DOI: 10.3390/nu14040768
Abstract: Metabolic detoxification (detox)—or biotransformation—is a physiological function that removes toxic substances from our body. Genetic variability and dietary factors may affect the function of detox enzymes, thus impacting the body’s sensitivity to toxic substances of… read more here.
Keywords: genetic biomarkers; medicine; biomarkers metabolic; detoxification ... See more keywords
The Associations between Preoperative Conventional MRI Features and Genetic Biomarkers Status in Newly Diagnosed GBMs: A Clinical Summary and Prognostic Analysis.
Sign Up to like & getrecommendations! Published in 2020 at "Turkish neurosurgery"
DOI: 10.5137/1019-5149.jtn.30092-20.1
Abstract: AIM In radiogenomics, certain MRI features have been recently associated to predict genetic alterations. We analyzed certain MRI features as well as six major genetic biomarkers, investigated their associations, and evaluated their prognostic roles in… read more here.
Keywords: status; mri features; conventional mri; preoperative conventional ... See more keywords