Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment
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DOI: 10.1007/s11886-024-02118-2
Abstract: This review aims to evaluate the potential of CRISPR-based gene editing tools, particularly prime editors (PE), in treating genetic cardiac diseases. It seeks to answer how these tools can overcome current therapeutic limitations and explore… read more here.
Keywords: genetic cardiac; ipsc cms; medicine; disease modeling ... See more keywords
Detection of genetic cardiac diseases by Ca2+ transient profiles using machine learning methods
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DOI: 10.1038/s41598-018-27695-5
Abstract: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have revolutionized cardiovascular research. Abnormalities in Ca2+ transients have been evident in many cardiac disease models. We have shown earlier that, by exploiting computational machine learning methods, normal… read more here.
Keywords: machine; machine learning; ca2 transients; genetic cardiac ... See more keywords