Transport‐controlled growth decoupling for self‐induced protein expression with a glycerol‐repressible genetic circuit
Sign Up to like & getrecommendations! Published in 2024 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28697
Abstract: Decoupling cell formation from recombinant protein synthesis is a potent strategy to intensify bioprocesses. Escherichia coli strains with mutations in the glucose uptake components lack catabolite repression, display low growth rate, no overflow metabolism, and… read more here.
Keywords: genetic circuit; glycerol; expression; growth ... See more keywords
CELLM: Bridging Natural Language Processing and Synthetic Genetic Circuit Design with AI.
Sign Up to like & getrecommendations! Published in 2025 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.5c00391
Abstract: The complexity of the genetic circuit design limits accessibility and efficiency in synthetic biology. This study presents an integrated system that combines Cello software with large language models (DeepSeek-R1, Phi-4) and the LangChain framework in… read more here.
Keywords: genetic circuit; natural language; biology; language ... See more keywords
Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18630-2
Abstract: To perform their computational function, genetic circuits change states through a symphony of genetic parts that turn regulator expression on and off. Debugging is frustrated by an inability to characterize parts in the context of… read more here.
Keywords: circuit characterization; genetic circuit; ribosome usage; rna polymerase ... See more keywords
First-principles prediction of the information processing capacity of a simple genetic circuit.
Sign Up to like & getrecommendations! Published in 2020 at "Physical review. E"
DOI: 10.1103/physreve.102.022404
Abstract: Given the stochastic nature of gene expression, genetically identical cells exposed to the same environmental inputs will produce different outputs. This heterogeneity has been hypothesized to have consequences for how cells are able to survive… read more here.
Keywords: processing capacity; information processing; genetic circuit; information ... See more keywords
Construction of Bacillus thuringiensis Simulant Strains Suitable for Environmental Release
Sign Up to like & getrecommendations! Published in 2017 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.00126-17
Abstract: ABSTRACT For a surrogate bacterium to be used in outdoor studies, it is important to consider environmental and human safety and ease of detection. Recently, Bacillus thuringiensis, a popular bioinsecticide bacterium, has been gaining attention… read more here.
Keywords: genetic circuit; simulant strains; thuringiensis; thuringiensis simulant ... See more keywords
Harnessing flavonoids to control probiotic function: in situ application of a naringenin-responsive genetic circuit
Sign Up to like & getrecommendations! Published in 2025 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.02890-24
Abstract: ABSTRACT Efforts to improve probiotics’ capabilities through synthetic biology have recently increased. Using naturally occurring plant-based compounds, such as flavonoids, as inputs of genetic circuits introduced in probiotics is a promising strategy to enhance or… read more here.
Keywords: responsive genetic; circuit; genetic circuit; genetic circuits ... See more keywords
A Recombinase-Based Genetic Circuit for Heavy Metal Monitoring
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios12020122
Abstract: Rapid progress in the genetic circuit design enabled whole-cell biosensors (WCBs) to become prominent in detecting an extensive range of analytes with promise in many fields, from medical diagnostics to environmental toxicity assessment. However, several… read more here.
Keywords: recombinase based; genetic circuit; heavy metal;