Programmed ubiquitin acetylation using genetic code expansion reveals altered ubiquitination patterns
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13702
Abstract: Ubiquitination is a post‐translational modification (PTM) capable of being regulated by other PTMs, including acetylation. However, the biological consequences of acetylated ubiquitin (acUb) variants are poorly understood, due to their transient nature in vivo and… read more here.
Keywords: code expansion; acetylation; ubiquitination patterns; using genetic ... See more keywords
Expanding the Genetic Code for Neuronal Studies
Sign Up to like & getrecommendations! Published in 2020 at "Chembiochem"
DOI: 10.1002/cbic.202000300
Abstract: Genetic code expansion is one of the most powerful technologies in protein engineering. In addition to the 20 canonical amino acids, the expanded genetic code is supplemented by unnatural amino acids, which have artificial side… read more here.
Keywords: code expansion; amino acids; code; code neuronal ... See more keywords
Reflections on the Origin and Early Evolution of the Genetic Code
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202300048
Abstract: Examination of the genetic code (GeCo) reveals that amino acids coded by (A/U) codons display a large functional spectrum and bind RNA whereas, except for Arg, those coded by (G/C) codons do not. From a… read more here.
Keywords: genetic code; reflections origin; origin early; early evolution ... See more keywords
Xenobiology: State-of-the-Art, Ethics, and Philosophy of New-to-Nature Organisms.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in biochemical engineering/biotechnology"
DOI: 10.1007/10_2016_14
Abstract: The basic chemical constitution of all living organisms in the context of carbon-based chemistry consists of a limited number of small molecules and polymers. Until the twenty-first century, biology was mainly an analytical science and… read more here.
Keywords: synthetic biology; chemistry; philosophy; biology ... See more keywords
Optimal Evolution of the Standard Genetic Code.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular evolution"
DOI: 10.1007/s00239-020-09984-8
Abstract: The Standard Genetic Code (SGC) exists in every known organism on Earth. SGC evolution via early unique codon assignment, then later wobble, yields coding resembling the near-universal code. Below, later wobble is shown to also… read more here.
Keywords: evolution; code; codon assignment; optimal evolution ... See more keywords
The Quality of Genetic Code Models in Terms of Their Robustness Against Point Mutations
Sign Up to like & getrecommendations! Published in 2019 at "Bulletin of Mathematical Biology"
DOI: 10.1007/s11538-019-00603-2
Abstract: In this paper, we investigate the quality of selected models of theoretical genetic codes in terms of their robustness against point mutations. To deal with this problem, we used a graph representation including all possible… read more here.
Keywords: quality; code; point mutations; code models ... See more keywords
Genetic code expansion via integration of redundant amino acid assignment by finely tuning tRNA pools.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.07.010
Abstract: In all translation systems, the genetic code assigns codons to amino acids as building blocks of polypeptides, defining their chemical, structural and physiological properties. The canonical genetic code, however, utilizes only 20 proteinogenic amino acids… read more here.
Keywords: code expansion; amino acids; code; expansion via ... See more keywords
Expansion of the genetic code via expansion of the genetic alphabet.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2018.08.009
Abstract: Current methods to expand the genetic code enable site-specific incorporation of non-canonical amino acids (ncAAs) into proteins in eukaryotic and prokaryotic cells. However, current methods are limited by the number of codons possible, their orthogonality,… read more here.
Keywords: expansion genetic; genetic alphabet; genetic code; expansion ... See more keywords
Increasing the chemical space of proteins in living cells via genetic code expansion.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2020.07.012
Abstract: In recent years it has become possible to genetically encode an expanded set of designer amino acids with tailored chemical and physical properties (dubbed unnatural amino acids, UAAs) into proteins in living cells by expanding… read more here.
Keywords: increasing chemical; proteins living; chemical space; living cells ... See more keywords
New opportunities for genetic code expansion in synthetic yeast.
Sign Up to like & getrecommendations! Published in 2022 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2022.102691
Abstract: The synthetic yeast, Sc2.0, is nearing completion as consolidation of all 17 synthetic chromosomes into a single cell advances. This organism will be the first synthetic eukaryote and provides a highly plastic biological chassis built… read more here.
Keywords: code expansion; yeast; synthetic yeast; genetic code ... See more keywords
On Francis Crick, the genetic code, and a clever kid
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.02.058
Abstract: A few years ago, Francis Crick's son told me a story that I can't get out of my mind. I had contacted Michael Crick by email while digging through the background of the researchers who… read more here.
Keywords: code; crick genetic; francis crick; genetic code ... See more keywords