Genetic overlap between endometriosis and endometrial cancer: evidence from cross‐disease genetic correlation and GWAS meta‐analyses
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Medicine"
DOI: 10.1002/cam4.1445
Abstract: Epidemiological, biological, and molecular data suggest links between endometriosis and endometrial cancer, with recent epidemiological studies providing evidence for an association between a previous diagnosis of endometriosis and risk of endometrial cancer. We used genetic… read more here.
Keywords: cross disease; endometriosis endometrial; evidence; genetic correlation ... See more keywords
Evidence for genetic correlation between human cerebral white matter microstructure and inflammation
Sign Up to like & getrecommendations! Published in 2019 at "Human Brain Mapping"
DOI: 10.1002/hbm.24694
Abstract: White matter microstructure is affected by immune system activity via the actions of circulating pro‐inflammatory cytokines. Although white matter microstructure and inflammatory measures are significantly heritable, it is unclear if overlapping genetic factors influence these… read more here.
Keywords: genetic correlation; matter microstructure; white matter;
Genetic correlation, causal relationship, and shared loci between vitamin D and COVID‐19: A genome‐wide cross‐trait analysis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28780
Abstract: Observational studies have shown that vitamin D supplementation reduces the risk of COVID‐19 infection, yet little is known about the shared genomic architectures between them. Leveraging large‐scale genome‐wide association study (GWAS) summary statistics, we investigated… read more here.
Keywords: vitamin covid; genome wide; vitamin; genetic correlation ... See more keywords
Genetic parameter estimation of reproductive traits of Litopenaeus vannamei
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Ocean University of China"
DOI: 10.1007/s11802-017-3127-9
Abstract: In this study, the heritability, repeatability, phenotypic correlation, and genetic correlation of the reproductive and growth traits of L. vannamei were investigated and estimated. Eight traits of 385 shrimps from forty-two families, including the number… read more here.
Keywords: parameter estimation; genetic parameter; correlation; genetic correlation ... See more keywords
A unified framework for cross-population trait prediction by leveraging the genetic correlation of polygenic traits.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.03.002
Abstract: The development of polygenic risk scores (PRSs) has proved useful to stratify the general European population into different risk groups. However, PRSs are less accurate in non-European populations due to genetic differences across different populations.… read more here.
Keywords: framework; polygenic; genetic correlation; cross population ... See more keywords
Genetic susceptibility for schizophrenia after adjustment by genetic susceptibility for smoking: implications in identification of risk genes and genetic correlation with related traits.
Sign Up to like & getrecommendations! Published in 2023 at "Psychological medicine"
DOI: 10.1017/s0033291723000326
Abstract: BACKGROUND Prevalence of smoking in schizophrenia (SCZ) is larger than in general population. Genetic studies provided some evidence of a causal effect of smoking on SCZ. We aim to characterize the genetic susceptibility to SCZ… read more here.
Keywords: smoking; genetic susceptibility; genetic correlation; analysis ... See more keywords
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10310-0
Abstract: Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, MiXeR, which quantifies polygenic… read more here.
Keywords: bivariate causal; correlation; genetic correlation; complex traits ... See more keywords
An integrated framework for local genetic correlation analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Nature genetics"
DOI: 10.1038/s41588-022-01017-y
Abstract: Genetic correlation (rg) analysis is used to identify phenotypes that may have a shared genetic basis. Traditionally, rg is studied globally, considering only the average of the shared signal across the genome, although this approach… read more here.
Keywords: correlation; analysis; framework local; correlation analysis ... See more keywords
Negative intersexual genetic correlation for colour pattern in a variable aposematic insect
Sign Up to like & getrecommendations! Published in 2021 at "Biological Journal of The Linnean Society"
DOI: 10.1093/biolinnean/blab025
Abstract: Despite the fact their coloration functions as an aposematic signal, and is thus expected to be under stabilizing selection, hibiscus harlequin bugs (Tectocoris diophthalmus) show an impressive level of variation in their iridescent coloration both… read more here.
Keywords: colour; negative intersexual; intersexual genetic; coloration ... See more keywords
Insights from Mendelian randomization and genetic correlation analyses into the relationship between endometriosis and its comorbidities.
Sign Up to like & getrecommendations! Published in 2023 at "Human reproduction update"
DOI: 10.1093/humupd/dmad009
Abstract: BACKGROUND Endometriosis remains a poorly understood disease, despite its high prevalence and debilitating symptoms. The overlap in symptoms and the increased risk of multiple other traits in women with endometriosis is becoming increasingly apparent through… read more here.
Keywords: genetic correlation; mendelian randomization; relationship endometriosis; endometriosis ... See more keywords
Characterization of Water Intake and Water Efficiency in beef cattle.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of animal science"
DOI: 10.1093/jas/skz354
Abstract: In the future, water may not be as readily available due to increases in competition from a growing human population, wildlife, and other agricultural sectors, making selection for water efficiency of beef cattle increasingly important.… read more here.
Keywords: water; water intake; genetic correlation; water efficiency ... See more keywords