Characterization of Oncology Clinical Trials Using Germline Genetic Data
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.42370
Abstract: This cross-sectional study evaluates the features of oncology clinical trials that use germline genetic data. read more here.
Keywords: oncology; genetic data; oncology clinical; germline genetic ... See more keywords
Inferring archaic introgression from hominin genetic data
Sign Up to like & getrecommendations! Published in 2021 at "Evolutionary Anthropology"
DOI: 10.1002/evan.21895
Abstract: Questions surrounding the timing, extent, and evolutionary consequences of archaic admixture into human populations have a long history in evolutionary anthropology. More recently, advances in human genetics, particularly in the field of ancient DNA, have… read more here.
Keywords: anthropology; archaic introgression; introgression hominin; genetic data ... See more keywords
Clinical and genetic data of 22 new patients with SMAD3 pathogenic variants and review of the literature
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Genetics & Genomic Medicine"
DOI: 10.1002/mgg3.1132
Abstract: Pathogenic SMAD3 variants are responsible for a cardiovascular phenotype, mainly thoracic aortic aneurysms and dissections. Precocious identification of the vascular risk such as aortic dilatation in mutated patients has a major impact in terms of… read more here.
Keywords: genetic data; clinical genetic; patients smad3; data new ... See more keywords
Temporal landscape genetic data indicate an ongoing disruption of gene flow in a relict bird species
Sign Up to like & getrecommendations! Published in 2020 at "Conservation Genetics"
DOI: 10.1007/s10592-020-01253-x
Abstract: A major concern in conservation biology today is the loss of genetic diversity in structured populations, which is often a consequence of habitat contraction and restricted gene flow over time. These dynamic biological processes require… read more here.
Keywords: disruption gene; gene flow; landscape genetic; genetic data ... See more keywords
Integration of georeferenced and genetic data for the management of biodiversity in sheep genetic resources in Brazil
Sign Up to like & getrecommendations! Published in 2021 at "Tropical Animal Health and Production"
DOI: 10.1007/s11250-021-02573-x
Abstract: There are few animal germplasm/gene bank collections in Brazil, and basic studies are needed to attend the future internal and external demands from international partners. The aim of this work was to validate a “proof… read more here.
Keywords: gene bank; samples gene; conservation; genetic data ... See more keywords
Equalden.HD: An R Package for testing the equality of a high dimensional set of densities.
Sign Up to like & getrecommendations! Published in 2022 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2022.106694
Abstract: BACKGROUND AND OBJECTIVE Nowadays the "low sample size, large dimension" scenario is often encountered in genetics and in the omic sciences, where the microarray data is typically formed by a large number of possibly dependent… read more here.
Keywords: sample; package; test; equalden package ... See more keywords
Review: Reversed low-rank ANOVA model for transforming high dimensional genetic data into low dimension
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Korean Statistical Society"
DOI: 10.1016/j.jkss.2018.10.002
Abstract: Abstract A general modeling procedure for analyzing genetic data is reviewed. We review ANOVA type model that can handle both the continuous and discrete genetic variables in one modeling framework. Unlike the regression type models… read more here.
Keywords: phenotype variable; genetic data; high dimensional; model ... See more keywords
Strategies for multivariate analyses of imaging genetics study in Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.136147
Abstract: Alzheimer's disease (AD) is an incurable neurodegenerative disease primarily affecting the elderly population. Early diagnosis of AD is critical for the management of this disease. Imaging genetics examines the influence of genetic variants (i.e., single… read more here.
Keywords: alzheimer disease; genetics; imaging genetics; disease ... See more keywords
Prospective parents should be prepared for a surge in genetic data
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/d41586-019-00331-6
Abstract: The growing capabilities of prenatal diagnostics are expanding the need for counselling.The growing capabilities of prenatal diagnostics are expanding the need for counselling. read more here.
Keywords: prepared surge; genetic data; parents prepared; prospective parents ... See more keywords
Genetic data and cognitively defined late-onset Alzheimer’s disease subgroups
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0298-8
Abstract: Categorizing people with late-onset Alzheimer’s disease into biologically coherent subgroups is important for personalized medicine. We evaluated data from five studies (total n = 4050, of whom 2431 had genome-wide single-nucleotide polymorphism (SNP) data). We assigned people… read more here.
Keywords: late onset; cognitively defined; alzheimer disease; disease ... See more keywords
How Sensitive Is Genetic Data
Sign Up to like & getrecommendations! Published in 2017 at "Biopreservation and Biobanking"
DOI: 10.1089/bio.2017.0033
Abstract: The rising demand to use genetic data for research goes hand in hand with an increased awareness of privacy issues related to its use. Using human genetic data in a legally compliant way requires an… read more here.
Keywords: sensitive genetic; disclosure; research; genetic data ... See more keywords