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   Articles with "genetic deletion" as a keyword



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Genetic deletion of NMDA receptors suppresses GABAergic synaptic transmission in two distinct types of central neurons

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recommendations! Published in 2018 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2018.01.024

Abstract: NMDA-type ionotropic glutamate receptors (NMDARs) play an important role in the regulation of synapse development and function in the brain. Recently we have shown that NMDARs are critical for GABAergic synapse development in developing hippocampal… read more here.

Keywords: transmission two; synaptic transmission; gabaergic synaptic; development ... See more keywords
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Impact of genetic deletion of MrgD or Mas receptors in depressive-like behavior in mice.

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recommendations! Published in 2022 at "Acta neuropsychiatrica"

DOI: 10.1017/neu.2022.20

Abstract: OBJECTIVES To evaluate the impact of genetic deletion of receptors of the counterregulatory arms of the renin-angiotensin system in depressive-like behaviors. METHODS 8-12 weeks-old male mice wild-type (WT, C57BL/6J) and mice with genetic deletion of… read more here.

Keywords: mrgd; depressive like; like behavior; mas ... See more keywords

Abstract 13405: Genetic Deletion of Stimulator of Interferon Genes Attenuates Atherogenesis in Apolipoprotein E-deficient Mice

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recommendations! Published in 2020 at "Circulation"

DOI: 10.1161/circ.142.suppl_3.13405

Abstract: Introduction: Recent studies show the contribution of innate immunity system to the pathogenesis of inflammatory diseases, including atherosclerosis. Stimulation of interferon genes (STING), origin... read more here.

Keywords: deletion stimulator; interferon; abstract 13405; 13405 genetic ... See more keywords
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Genetic deletion of Rnd3 in neural stem cells promotes proliferation via upregulation of Notch signaling

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recommendations! Published in 2017 at "Oncotarget"

DOI: 10.18632/oncotarget.20247

Abstract: Rnd3, a Rho GTPase, is involved in the inhibition of actin cytoskeleton dynamics through the Rho kinase-dependent signaling pathway. We previously demonstrated that mice with genetic deletion of Rnd3 developed a markedly larger brain compared… read more here.

Keywords: notch signaling; neural stem; rnd3; genetic deletion ... See more keywords
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Genetic Deletion of KLHL1 Leads to Hyperexcitability in Hypothalamic POMC Neurons and Lack of Electrical Responses to Leptin

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recommendations! Published in 2021 at "Frontiers in Neuroscience"

DOI: 10.3389/fnins.2021.718464

Abstract: Kelch-like 1 (KLHL1) is a neuronal actin-binding protein that modulates voltage-gated calcium channels. The KLHL1 knockout (KO) model displays altered calcium channel expression in various brain regions. We analyzed the electrical behavior of hypothalamic POMC… read more here.

Keywords: pomc neurons; type channels; deletion klhl1; hypothalamic pomc ... See more keywords