CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Cell Systems"
DOI: 10.1016/j.cels.2017.06.002
Abstract: Summary Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale… read more here.
Keywords: interpreting genetic; genetic dependencies; cancergd resource; resource identifying ... See more keywords
Abstract 4306: Identifying genetic dependencies of replication stress using interpretable artificial intelligence
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4306
Abstract: Rapid proliferation is a hallmark of tumor cells, associated with sensitivity to chemicals that cause DNA replication stress (RS). Due to sustained proliferative signaling and/or defective DNA repair, cancer cells undergo persistent RS making them… read more here.
Keywords: stress; replication; replication stress; genetic dependencies ... See more keywords
Complex genetic dependencies among growth and neurological phenotypes in healthy children: Towards deciphering developmental mechanisms
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DOI: 10.1371/journal.pone.0242684
Abstract: The genetic mechanisms of childhood development in its many facets remain largely undeciphered. In the population of healthy infants studied in the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) program, we have identified a… read more here.
Keywords: genetic dependencies; dependencies among; complex genetic; growth ... See more keywords