Genetic determinants of antidepressant and antipsychotic drug response
Sign Up to like & getrecommendations! Published in 2024 at "European Archives of Psychiatry and Clinical Neuroscience"
DOI: 10.1007/s00406-024-01918-5
Abstract: Today, more than 90% of inpatients hospitalized with Major Depression or Schizophrenia are treated with psychotropic drugs. Since none of the treatment options is causal, response rates are modest and the course of recovery is… read more here.
Keywords: treatment; etiology; genotypic patterns; response ... See more keywords
Integrative Approaches Identify Genetic Determinants of Levodopa Induced Dyskinesia
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Neurobiology"
DOI: 10.1007/s12035-025-04930-5
Abstract: Levodopa induced dyskinesia (LID) is a serious side effect of levodopa treatment in Parkinson’s disease (PD), with limited interventions. Understanding the genetic impact on LID would help inform future intervention studies. We performed integrative genomic… read more here.
Keywords: approaches identify; levodopa induced; genetic determinants; identify genetic ... See more keywords
Genetic Determinants of P2Y12 Inhibitors and Clinical Implications.
Sign Up to like & getrecommendations! Published in 2017 at "Interventional cardiology clinics"
DOI: 10.1016/j.iccl.2016.08.010
Abstract: There is significant interpatient variability in clopidogrel effectiveness, which is due in part to cytochrome P450 (CYP) 2C19 genotype. Approximately 30% of individuals carry CYP2C19 loss-of-function alleles, which have been consistently shown to reduce clopidogrel… read more here.
Keywords: genetic determinants; cardiology; clinical implications; inhibitors clinical ... See more keywords
Genetic determinants of glycated hemoglobin levels in the Greenlandic Inuit population
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-018-0109-3
Abstract: We previously showed that a common genetic variant leads to a remarkably increased risk of type 2 diabetes (T2D) in the small and historically isolated Greenlandic population. Motivated by this, we aimed at discovering novel… read more here.
Keywords: genetic determinants; determinants glycated; inuit; hba1c ... See more keywords
Genetic determinants and epigenetic effects of pioneer factor occupancy
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/s41588-017-0034-3
Abstract: Transcription factors (TFs) direct developmental transitions by binding to target DNA sequences, influencing gene expression and establishing complex gene-regultory networks. To systematically determine the molecular components that enable or constrain TF activity, we investigated the… read more here.
Keywords: genetic determinants; pioneer factor; determinants epigenetic; effects pioneer ... See more keywords
Genetic Determinants of Antibody-Mediated Immune Responses to Infectious Diseases Agents: A Genome-Wide and HLA Association Study
Sign Up to like & getrecommendations! Published in 2020 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofaa450
Abstract: Abstract Background Infectious diseases are causally related to a large array of noncommunicable diseases (NCDs). Identifying genetic determinants of infections and antibody-mediated immune responses may shed light on this relationship and provide therapeutic targets for… read more here.
Keywords: genetic determinants; genome wide; mediated immune; infectious diseases ... See more keywords
Antimicrobial resistance genetic determinants and susceptibility profile of Pseudomonas aeruginosa isolated from clinical samples in a tertiary hospital in Ogun State, Nigeria.
Sign Up to like & getrecommendations! Published in 2024 at "Transactions of the Royal Society of Tropical Medicine and Hygiene"
DOI: 10.1093/trstmh/trae012
Abstract: BACKGROUND Genetic determinants are known to promote antibiotic resistance through horizontal gene transfer. METHODS We molecularly characterized integrons, plasmid replicon types and metallo-β-lactamase-encoding genes of 38 Pseudomonas aeruginosa strains isolated from clinical samples. RESULTS The… read more here.
Keywords: isolated clinical; resistance; pseudomonas aeruginosa; clinical samples ... See more keywords
The search for genetic determinants of human neural tube defects.
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Pediatrics"
DOI: 10.1097/mop.0000000000000817
Abstract: PURPOSE OF REVIEW An update is presented regarding neural tube defects (NTDs) including spina bifida and anencephaly, which are among the most common serious birth defects world-wide. Decades of research suggest that no single factor… read more here.
Keywords: neural tube; determinants human; search genetic; tube ... See more keywords
Genetic determinants associated with response to clozapine in schizophrenia: an umbrella review
Sign Up to like & getrecommendations! Published in 2022 at "Psychiatric Genetics"
DOI: 10.1097/ypg.0000000000000320
Abstract: Objective Clozapine response varies widely from person to person, which may be due to inter-individual genetic variability. This umbrella review aims to summarize the current evidence on associations between pharmacodynamic genes and response to clozapine… read more here.
Keywords: clozapine response; genetic determinants; response clozapine; clozapine ... See more keywords
Genetic determinants of BMI from early childhood to adolescence: the Santiago Longitudinal Study
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Obesity"
DOI: 10.1111/ijpo.12479
Abstract: While the genetic contribution to obesity is well established, few studies have examined how genetic variants influence standardized body mass index Z‐score (BMIz) in Hispanics/Latinos, especially across childhood and adolescence. read more here.
Keywords: genetic determinants; determinants bmi; bmi early; childhood adolescence ... See more keywords
Clinical and genetic determinants of urinary glucose excretion in patients with diabetes mellitus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Diabetes Investigation"
DOI: 10.1111/jdi.13417
Abstract: Glucosuria is a representative symptom in diabetes patients with poor glycemic control and in those treated with sodium–glucose cotransporter 2 inhibitors. Renal threshold levels of glucose excretion are known to vary among individuals, but factors… read more here.
Keywords: genetic determinants; glucose excretion; clinical genetic; determinants urinary ... See more keywords