Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/mp.2018.6
Abstract: Employed family-based genetic discovery combining linkage analysis and exome sequencing to identify RCL1 as a novel candidate gene for depression, with independent replication in a population-based cohort read more here.
Keywords: genetic discovery; combining linkage; discovery combining; employed family ... See more keywords
Hidden heritability due to heterogeneity across seven populations
Sign Up to like & getrecommendations! Published in 2017 at "Nature human behaviour"
DOI: 10.1038/s41562-017-0195-1
Abstract: Meta-analyses of genome-wide association studies, which dominate genetic discovery, are based on data from diverse historical time periods and populations. Genetic scores derived from genome-wide association studies explain only a fraction of the heritability estimates… read more here.
Keywords: genetic discovery; heterogeneity across; heritability; seven populations ... See more keywords