Genetic disruption of Ano5 leads to impaired osteoclastogenesis for gnathodiaphyseal dysplasia.
Sign Up to like & getrecommendations! Published in 2023 at "Oral diseases"
DOI: 10.1111/odi.14562
Abstract: OBJECTIVES Gnathodiaphyseal dysplasia (GDD; OMIM#166260) is a rare skeletal genetic disorder characterized by sclerosis of tubular bones and cemento-osseous lesions in mandibles. TMEM16E/ANO5 gene mutations have been identified in patients with GDD. Here, Ano5 knockout… read more here.
Keywords: osteoclastogenesis; genetic disruption; ano5 mice; ano5 ... See more keywords
Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019003530
Abstract: Oncogenic RAS mutations pose substantial challenges for rational drug discovery. Sequence variations within the hypervariable region (HVR) of Ras isoforms underlie differential post-translational modification and subcellular trafficking, potentially resulting in selective vulnerabilities. Specifically, inhibiting the… read more here.
Keywords: palmitoylation; genetic disruption; mice; myeloid transformation ... See more keywords
Erratum. Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet–Induced Glucose Intolerance. Diabetes 2017;66:1928–1938
Sign Up to like & getrecommendations! Published in 2017 at "Diabetes"
DOI: 10.2337/db17-er12f
Abstract: In the article listed above, Yassan Abdolazimi’s name was inadvertently misspelled in the … read more here.
Keywords: mouse pancreatic; adenosine kinase; genetic disruption; kinase mouse ... See more keywords
Augmented Cardiac Growth Hormone Signaling Contributes to Cardiomyopathy Following Genetic Disruption of the Cardiomyocyte Circadian Clock
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.836725
Abstract: Circadian clocks regulate numerous biological processes, at whole body, organ, and cellular levels. This includes both hormone secretion and target tissue sensitivity. Although growth hormone (GH) secretion is time-of-day-dependent (increased pulse amplitude during the sleep… read more here.
Keywords: genetic disruption; cardiomyocyte circadian; cardiomyocyte; circadian clock ... See more keywords