Perampanel as precision therapy in rare genetic epilepsies
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DOI: 10.1111/epi.17530
Abstract: Perampanel, an antiseizure drug with α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor antagonist properties, may have a targeted effect in genetic epilepsies with overwhelming glutamate receptor activation. Epilepsies with loss of γ‐aminobutyric acid inhibition (e.g., SCN1A), overactive excitatory neurons… read more here.
Keywords: precision therapy; therapy rare; rare genetic; perampanel precision ... See more keywords
Drosophila melanogaster as a versatile model organism to study genetic epilepsies: An overview
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1116000
Abstract: Epilepsy is one of the most prevalent neurological disorders, affecting more than 45 million people worldwide. Recent advances in genetic techniques, such as next-generation sequencing, have driven genetic discovery and increased our understanding of the… read more here.
Keywords: versatile model; model; model organism; genetic epilepsies ... See more keywords